Modeling the effect of blood vessel bifurcation ratio on occlusive thrombus formation

Hari Hara Sudhan Lakshmanan, Joseph J. Shatzel, Sven R. Olson, Owen J.T. McCarty, Jeevan Maddala

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Vascular geometry is a major determinant of the hemodynamics that promote or prevent unnecessary vessel occlusion from thrombus formation. Bifurcations in the vascular geometry are repeating structures that introduce flow separation between parent and daughter vessels. We modelled the blood flow and shear rate in a bifurcation during thrombus formation and show that blood vessel bifurcation ratios determine the maximum shear rate on the surface of a growing thrombus. We built an analytical model that may aid in predicting microvascular bifurcation ratios that are prone to occlusive thrombus formation. We also observed that bifurcation ratios that adhere to Murray’s law of bifurcations may be protected from occlusive thrombus formation. These results may be useful in the rational design of diagnostic microfluidic devices and microfluidic blood oxygenators.

Original languageEnglish (US)
Pages (from-to)972-980
Number of pages9
JournalComputer Methods in Biomechanics and Biomedical Engineering
Volume22
Issue number11
DOIs
StatePublished - Aug 18 2019

Keywords

  • Shear rate
  • bifurcation
  • blood
  • hemodynamics
  • microvasculature
  • occlusion

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering
  • Human-Computer Interaction
  • Computer Science Applications

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