Modeling subdiffusive light scattering by incorporating the tissue phase function and detector numerical aperture

Anouk L. Post, Steven Jacques, Henricus J.C.M. Sterenborg, DIrk J. Faber, Ton G. Van Leeuwen

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

To detect small-scale changes in tissue with optical techniques, small sampling volumes and, therefore, short source-detector separations are required. In this case, reflectance measurements are not adequately described by the diffusion approximation. Previous studies related subdiffusive reflectance to γ or σ which parameterize the phase function. Recently, it was demonstrated that σ predicts subdiffusive reflectance better than γ, and that σ becomes less predictive for lower numerical apertures (NAs). We derive and evaluate the parameter RpNA, which incorporates the NA of the detector and the integral of the phase function over the NA in the backward and forward directions. Monte Carlo simulations are performed for overlapping source/detector geometries for a range of phase functions, reduced scattering coefficients, NAs, and source/detector diameters. RpNA improves prediction of the measured reflectance compared to γ and σ. It is, therefore, expected that RpNA will improve derivation of optical properties from subdiffusive measurements.

Original languageEnglish (US)
Article number050501
JournalJournal of Biomedical Optics
Volume22
Issue number5
DOIs
StatePublished - 2017

Keywords

  • backscattering
  • optical properties
  • reflectance spectroscopy
  • scattering phase function
  • subdiffusive scattering

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Biomedical Engineering

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