Modeling dendrite density from magnetic resonance diffusion measurements

Sune N. Jespersen, Christopher (Chris) Kroenke, Leif Østergaard, Joseph J H Ackerman, Dmitriy A. Yablonskiy

Research output: Contribution to journalArticle

173 Citations (Scopus)

Abstract

Diffusion-weighted imaging (DWI) provides a noninvasive tool to probe tissue microstructure. We propose a simplified model of neural cytoarchitecture intended to capture the essential features important for water diffusion as measured by NMR. Two components contribute to the NMR signal in this model: (i) the dendrites and axons, which are modeled as long cylinders with two diffusion coefficients, parallel (DL) and perpendicular (DT) to the cylindrical axis, and (ii) an isotropic monoexponential diffusion component describing water diffusion within and across all other structures, i.e., in extracellular space and glia cells. The model parameters are estimated from 153 diffusion-weighted images acquired from a formalin-fixed baboon brain. A close correspondence between the data and the signal model is found, with the model parameters consistent with literature values. The model provides an estimate of dendrite density from noninvasive MR diffusion measurements, a parameter likely to be of value for understanding normal as well as abnormal brain development and function.

Original languageEnglish (US)
Pages (from-to)1473-1486
Number of pages14
JournalNeuroImage
Volume34
Issue number4
DOIs
StatePublished - Feb 15 2007
Externally publishedYes

Fingerprint

Dendrites
Magnetic Resonance Spectroscopy
Water
Papio
Brain
Extracellular Space
Neuroglia
Formaldehyde
Axons
Reference Values

Keywords

  • Cytoarchitectonics
  • Diffusion
  • Neural tissue
  • Spherical harmonics

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Jespersen, S. N., Kroenke, C. C., Østergaard, L., Ackerman, J. J. H., & Yablonskiy, D. A. (2007). Modeling dendrite density from magnetic resonance diffusion measurements. NeuroImage, 34(4), 1473-1486. https://doi.org/10.1016/j.neuroimage.2006.10.037

Modeling dendrite density from magnetic resonance diffusion measurements. / Jespersen, Sune N.; Kroenke, Christopher (Chris); Østergaard, Leif; Ackerman, Joseph J H; Yablonskiy, Dmitriy A.

In: NeuroImage, Vol. 34, No. 4, 15.02.2007, p. 1473-1486.

Research output: Contribution to journalArticle

Jespersen, SN, Kroenke, CC, Østergaard, L, Ackerman, JJH & Yablonskiy, DA 2007, 'Modeling dendrite density from magnetic resonance diffusion measurements', NeuroImage, vol. 34, no. 4, pp. 1473-1486. https://doi.org/10.1016/j.neuroimage.2006.10.037
Jespersen, Sune N. ; Kroenke, Christopher (Chris) ; Østergaard, Leif ; Ackerman, Joseph J H ; Yablonskiy, Dmitriy A. / Modeling dendrite density from magnetic resonance diffusion measurements. In: NeuroImage. 2007 ; Vol. 34, No. 4. pp. 1473-1486.
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