Model-based reconstruction for undersampled dynamic contrast-enhanced MRI

Ben K. Felsted, Ross T. Whitaker, Matthias Schabel, Edward V.R. DiBell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

This paper describes a method for estimating, from dynamic contrast-enhanced MRI raw k-space data of the breast, parameter maps that model tissue properties associated with a compartmental model of contrast exchange. The contrast agent kinetics, as represented by these parameter maps, are important in distinguishing benign and malignant tumors. The proposed model-based reconstruction algorithm estimates tissue parameter maps directly from MRI k-space data, thereby allowing a new and improved set of spatiotemporal resolution and noise tradeoffs. Realistic noise levels and an undersampling factor of R=4 appeared to provide reasonable accuracy for the kinetic parameters of interest.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2009
Subtitle of host publicationBiomedical Applications in Molecular, Structural, and Functional Imaging
DOIs
StatePublished - Jun 22 2009
EventMedical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging - Lake Buena Vista, FL, United States
Duration: Feb 8 2009Feb 10 2009

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7262
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging
CountryUnited States
CityLake Buena Vista, FL
Period2/8/092/10/09

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Keywords

  • Breast imaging
  • Dynamic contrast-enhanced magnetic resonance imaging
  • Iterative reconstruction
  • Model-based reconstruction
  • Pharmacokinetic modeling
  • Undersampled k-space

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Felsted, B. K., Whitaker, R. T., Schabel, M., & DiBell, E. V. R. (2009). Model-based reconstruction for undersampled dynamic contrast-enhanced MRI. In Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging [72622S] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7262). https://doi.org/10.1117/12.813991