Modal shifts in acetylcholine receptor channel gating confer subunit-dependent desensitization

David Naranjo, Paul Brehm

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

During the transition from embryonic to adult skeletal muscle, a decreased mean channel open time and accelerated desensitization of nicotinic acetylcholine (ACh) receptors result from the substitution of an ∈ subunit for γ. A single ACh receptor channel of the embryonic type expressed in Xenopus oocytes, interconverts between gating modes of short and long open time whereas the adult receptor channel resides almost exclusively in the gating mode with short open time. Differences in the fraction of time spent in either gating mode account for the subunit dependence of both receptor open time and desensitization. Therefore, developmental changes in the kinetics of muscle ACh receptors may be imparted through subunit-dependent stabilization of intrinsic gating modes.

Original languageEnglish (US)
Pages (from-to)1811-1814
Number of pages4
JournalScience
Volume260
Issue number5115
StatePublished - Jun 18 1993
Externally publishedYes

Fingerprint

Cholinergic Receptors
Nicotinic Receptors
Xenopus
Oocytes
Skeletal Muscle
Muscles

ASJC Scopus subject areas

  • General

Cite this

Modal shifts in acetylcholine receptor channel gating confer subunit-dependent desensitization. / Naranjo, David; Brehm, Paul.

In: Science, Vol. 260, No. 5115, 18.06.1993, p. 1811-1814.

Research output: Contribution to journalArticle

@article{bd43ff24d0b54fa2b3d530563de770a1,
title = "Modal shifts in acetylcholine receptor channel gating confer subunit-dependent desensitization",
abstract = "During the transition from embryonic to adult skeletal muscle, a decreased mean channel open time and accelerated desensitization of nicotinic acetylcholine (ACh) receptors result from the substitution of an ∈ subunit for γ. A single ACh receptor channel of the embryonic type expressed in Xenopus oocytes, interconverts between gating modes of short and long open time whereas the adult receptor channel resides almost exclusively in the gating mode with short open time. Differences in the fraction of time spent in either gating mode account for the subunit dependence of both receptor open time and desensitization. Therefore, developmental changes in the kinetics of muscle ACh receptors may be imparted through subunit-dependent stabilization of intrinsic gating modes.",
author = "David Naranjo and Paul Brehm",
year = "1993",
month = "6",
day = "18",
language = "English (US)",
volume = "260",
pages = "1811--1814",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5115",

}

TY - JOUR

T1 - Modal shifts in acetylcholine receptor channel gating confer subunit-dependent desensitization

AU - Naranjo, David

AU - Brehm, Paul

PY - 1993/6/18

Y1 - 1993/6/18

N2 - During the transition from embryonic to adult skeletal muscle, a decreased mean channel open time and accelerated desensitization of nicotinic acetylcholine (ACh) receptors result from the substitution of an ∈ subunit for γ. A single ACh receptor channel of the embryonic type expressed in Xenopus oocytes, interconverts between gating modes of short and long open time whereas the adult receptor channel resides almost exclusively in the gating mode with short open time. Differences in the fraction of time spent in either gating mode account for the subunit dependence of both receptor open time and desensitization. Therefore, developmental changes in the kinetics of muscle ACh receptors may be imparted through subunit-dependent stabilization of intrinsic gating modes.

AB - During the transition from embryonic to adult skeletal muscle, a decreased mean channel open time and accelerated desensitization of nicotinic acetylcholine (ACh) receptors result from the substitution of an ∈ subunit for γ. A single ACh receptor channel of the embryonic type expressed in Xenopus oocytes, interconverts between gating modes of short and long open time whereas the adult receptor channel resides almost exclusively in the gating mode with short open time. Differences in the fraction of time spent in either gating mode account for the subunit dependence of both receptor open time and desensitization. Therefore, developmental changes in the kinetics of muscle ACh receptors may be imparted through subunit-dependent stabilization of intrinsic gating modes.

UR - http://www.scopus.com/inward/record.url?scp=0027325659&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027325659&partnerID=8YFLogxK

M3 - Article

VL - 260

SP - 1811

EP - 1814

JO - Science

JF - Science

SN - 0036-8075

IS - 5115

ER -