Modafinil reinstates a cocaine conditioned place preference following extinction in rats

Rick E. Bernardi, Jason R. Lewis, K. Matthew Lattal, S. Paul Berger

Research output: Contribution to journalArticle

27 Scopus citations


The current study examined whether modafinil would reinstate an extinguished cocaine conditioned place preference (CPP). Following extinction of a cocaine CPP, rats were administered modafinil (128 mg/kg), cocaine (5 mg/kg) or vehicle and given a 60-min reinstatement test. While the effect of cocaine was transient, modafinil robustly reinstated a cocaine CPP following extinction, suggesting that modafinil may induce relapse or increase the vulnerability of addicts to the reinforcing effects of environmental triggers.

Original languageEnglish (US)
Pages (from-to)250-253
Number of pages4
JournalBehavioural Brain Research
Issue number1
StatePublished - Dec 1 2009



  • Cocaine
  • Conditioned place preference
  • Modafinil
  • Reinstatement

ASJC Scopus subject areas

  • Behavioral Neuroscience

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