Modafinil reinstates a cocaine conditioned place preference following extinction in rats

Rick E. Bernardi; Jason R. Lewis; K. Matthew Lattal; S. Paul Berger

doi:10.1016/j.bbr.2009.05.028

Modafinil reinstates a cocaine conditioned place preference following extinction in rats

Rick E. Bernardi, Jason R. Lewis, K. Matthew Lattal, S. Paul Berger

Behavioral Neuroscience

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

The current study examined whether modafinil would reinstate an extinguished cocaine conditioned place preference (CPP). Following extinction of a cocaine CPP, rats were administered modafinil (128 mg/kg), cocaine (5 mg/kg) or vehicle and given a 60-min reinstatement test. While the effect of cocaine was transient, modafinil robustly reinstated a cocaine CPP following extinction, suggesting that modafinil may induce relapse or increase the vulnerability of addicts to the reinforcing effects of environmental triggers.

Original language	English (US)
Pages (from-to)	250-253
Number of pages	4
Journal	Behavioural Brain Research
Volume	204
Issue number	1
DOIs	https://doi.org/10.1016/j.bbr.2009.05.028
State	Published - Dec 1 2009

Keywords

Cocaine
Conditioned place preference
Modafinil
Reinstatement

ASJC Scopus subject areas

Behavioral Neuroscience

Access to Document

10.1016/j.bbr.2009.05.028

Cite this

@article{f243c66d6cce45fca69563b42f6e38bd,

title = "Modafinil reinstates a cocaine conditioned place preference following extinction in rats",

abstract = "The current study examined whether modafinil would reinstate an extinguished cocaine conditioned place preference (CPP). Following extinction of a cocaine CPP, rats were administered modafinil (128 mg/kg), cocaine (5 mg/kg) or vehicle and given a 60-min reinstatement test. While the effect of cocaine was transient, modafinil robustly reinstated a cocaine CPP following extinction, suggesting that modafinil may induce relapse or increase the vulnerability of addicts to the reinforcing effects of environmental triggers.",

keywords = "Cocaine, Conditioned place preference, Modafinil, Reinstatement",

author = "Bernardi, {Rick E.} and Lewis, {Jason R.} and Lattal, {K. Matthew} and Berger, {S. Paul}",

note = "Funding Information: This research was supported by a grant from the Department of Veterans Affairs Merit Review program (07-1003) to S. Paul Berger, grants from the National Institute of Mental Health (R01 MH077111) and National Institute on Drug Abuse (R01 DA025922) to K. Matthew Lattal, and grants from the National Institute on Drug Abuse (T32 DA007262 and F31 DA022844) to Rick E. Bernardi.",

year = "2009",

month = dec,

day = "1",

doi = "10.1016/j.bbr.2009.05.028",

language = "English (US)",

volume = "204",

pages = "250--253",

journal = "Behavioural Brain Research",

issn = "0166-4328",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Modafinil reinstates a cocaine conditioned place preference following extinction in rats

AU - Bernardi, Rick E.

AU - Lewis, Jason R.

AU - Lattal, K. Matthew

AU - Berger, S. Paul

N1 - Funding Information: This research was supported by a grant from the Department of Veterans Affairs Merit Review program (07-1003) to S. Paul Berger, grants from the National Institute of Mental Health (R01 MH077111) and National Institute on Drug Abuse (R01 DA025922) to K. Matthew Lattal, and grants from the National Institute on Drug Abuse (T32 DA007262 and F31 DA022844) to Rick E. Bernardi.

PY - 2009/12/1

Y1 - 2009/12/1

N2 - The current study examined whether modafinil would reinstate an extinguished cocaine conditioned place preference (CPP). Following extinction of a cocaine CPP, rats were administered modafinil (128 mg/kg), cocaine (5 mg/kg) or vehicle and given a 60-min reinstatement test. While the effect of cocaine was transient, modafinil robustly reinstated a cocaine CPP following extinction, suggesting that modafinil may induce relapse or increase the vulnerability of addicts to the reinforcing effects of environmental triggers.

AB - The current study examined whether modafinil would reinstate an extinguished cocaine conditioned place preference (CPP). Following extinction of a cocaine CPP, rats were administered modafinil (128 mg/kg), cocaine (5 mg/kg) or vehicle and given a 60-min reinstatement test. While the effect of cocaine was transient, modafinil robustly reinstated a cocaine CPP following extinction, suggesting that modafinil may induce relapse or increase the vulnerability of addicts to the reinforcing effects of environmental triggers.

KW - Cocaine

KW - Conditioned place preference

KW - Modafinil

KW - Reinstatement

UR - http://www.scopus.com/inward/record.url?scp=67849130401&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67849130401&partnerID=8YFLogxK

U2 - 10.1016/j.bbr.2009.05.028

DO - 10.1016/j.bbr.2009.05.028

M3 - Article

C2 - 19482046

AN - SCOPUS:67849130401

SN - 0166-4328

VL - 204

SP - 250

EP - 253

JO - Behavioural Brain Research

JF - Behavioural Brain Research

IS - 1

ER -

Modafinil reinstates a cocaine conditioned place preference following extinction in rats

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this