MmpL11 protein transports mycolic acid-containing lipids to the mycobacterial cell wall and contributes to biofilm formation in Mycobacterium smegmatis

Sophia A. Pacheco, Fong Fu Hsu, Katelyn M. Powers, Georgiana Purdy

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Background: The role of the MmpL11 transporter in mycobacteria is not understood. Results: Mycobacterium smegmatis mmpL11 mutants accumulate mycolic acid precursors and fail to transport monomeromycolyl diacylglycerol and mycolate ester wax to the bacterial surface. Conclusion: MmpL11 contributes to mycobacterial cell wall biosynthesis. Significance: MmpL11 plays a conserved role in mycobacterial cell wall biogenesis that is important for M. tuberculosis virulence.

Original languageEnglish (US)
Pages (from-to)24213-24222
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number33
DOIs
StatePublished - Aug 16 2013

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Mycolic Acids
Mycobacterium smegmatis
Biofilms
Protein Transport
Cell Wall
Cells
Lipids
Waxes
Diglycerides
Biosynthesis
Mycobacterium
Virulence
Esters
Tuberculosis
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

MmpL11 protein transports mycolic acid-containing lipids to the mycobacterial cell wall and contributes to biofilm formation in Mycobacterium smegmatis. / Pacheco, Sophia A.; Hsu, Fong Fu; Powers, Katelyn M.; Purdy, Georgiana.

In: Journal of Biological Chemistry, Vol. 288, No. 33, 16.08.2013, p. 24213-24222.

Research output: Contribution to journalArticle

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