MmpL11 protein transports mycolic acid-containing lipids to the mycobacterial cell wall and contributes to biofilm formation in Mycobacterium smegmatis

Sophia A. Pacheco, Fong Fu Hsu, Katelyn M. Powers, Georgiana E. Purdy

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Background: The role of the MmpL11 transporter in mycobacteria is not understood. Results: Mycobacterium smegmatis mmpL11 mutants accumulate mycolic acid precursors and fail to transport monomeromycolyl diacylglycerol and mycolate ester wax to the bacterial surface. Conclusion: MmpL11 contributes to mycobacterial cell wall biosynthesis. Significance: MmpL11 plays a conserved role in mycobacterial cell wall biogenesis that is important for M. tuberculosis virulence.

Original languageEnglish (US)
Pages (from-to)24213-24222
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number33
DOIs
StatePublished - Aug 16 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'MmpL11 protein transports mycolic acid-containing lipids to the mycobacterial cell wall and contributes to biofilm formation in Mycobacterium smegmatis'. Together they form a unique fingerprint.

  • Cite this