Mmpl proteins in physiology and pathogenesis of m. Tuberculosis

Geoff Melly; Georgiana E. Purdy

doi:10.3390/microorganisms7030070

Mmpl proteins in physiology and pathogenesis of m. Tuberculosis

Geoff Melly, Georgiana E. Purdy

Molecular Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Mycobacterium tuberculosis (Mtb) remains an important human pathogen. The Mtb cell envelope is a critical bacterial structure that contributes to virulence and pathogenicity. Mycobacterial membrane protein large (MmpL) proteins export bulky, hydrophobic substrates that are essential for the unique structure of the cell envelope and directly support the ability of Mtb to infect and persist in the host. This review summarizes recent investigations that have enabled insight into the molecular mechanisms underlying MmpL substrate export and the role that these substrates play during Mtb infection.

Original language	English (US)
Article number	70
Journal	Microorganisms
Volume	7
Issue number	3
DOIs	https://doi.org/10.3390/microorganisms7030070
State	Published - Mar 2019

Keywords

Cell envelope
Lipid transport
Lipids
MmpL
Mycobacterium tuberculosis

ASJC Scopus subject areas

Microbiology
Microbiology (medical)
Virology

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10.3390/microorganisms7030070

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AB - Mycobacterium tuberculosis (Mtb) remains an important human pathogen. The Mtb cell envelope is a critical bacterial structure that contributes to virulence and pathogenicity. Mycobacterial membrane protein large (MmpL) proteins export bulky, hydrophobic substrates that are essential for the unique structure of the cell envelope and directly support the ability of Mtb to infect and persist in the host. This review summarizes recent investigations that have enabled insight into the molecular mechanisms underlying MmpL substrate export and the role that these substrates play during Mtb infection.

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Mmpl proteins in physiology and pathogenesis of m. Tuberculosis

Abstract

Keywords

ASJC Scopus subject areas

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