Mmpl proteins in physiology and pathogenesis of m. Tuberculosis

Geoff Melly, Georgiana E. Purdy

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Mycobacterium tuberculosis (Mtb) remains an important human pathogen. The Mtb cell envelope is a critical bacterial structure that contributes to virulence and pathogenicity. Mycobacterial membrane protein large (MmpL) proteins export bulky, hydrophobic substrates that are essential for the unique structure of the cell envelope and directly support the ability of Mtb to infect and persist in the host. This review summarizes recent investigations that have enabled insight into the molecular mechanisms underlying MmpL substrate export and the role that these substrates play during Mtb infection.

Original languageEnglish (US)
Article number70
JournalMicroorganisms
Volume7
Issue number3
DOIs
StatePublished - Mar 2019

Keywords

  • Cell envelope
  • Lipid transport
  • Lipids
  • MmpL
  • Mycobacterium tuberculosis

ASJC Scopus subject areas

  • Microbiology
  • Virology
  • Microbiology (medical)

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