MMP9 potentiates pulmonary metastasis formation

Léon C.L. Van Kempen; Lisa M. Coussens

doi:10.1016/S1535-6108(02)00157-5

MMP9 potentiates pulmonary metastasis formation

Léon C.L. Van Kempen, Lisa M. Coussens

Research output: Contribution to journal › Review article › peer-review

147 Scopus citations

Abstract

Tumor cell dissemination to distant organ sites is a complex process involving multiple cell types, soluble growth factors, adhesion receptors, and tissue remodeling. A new study in this issue of Cancer Cell shows that MMP9-expressing tumor-associated macrophages play a key role in prepping premetastatic sites for eventual malignant cell growth in a manner dependent upon vascular endothelial growth factor receptor-1 (VEGFR-1).

Original language	English (US)
Pages (from-to)	251-252
Number of pages	2
Journal	Cancer Cell
Volume	2
Issue number	4
DOIs	https://doi.org/10.1016/S1535-6108(02)00157-5
State	Published - Oct 2002
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/S1535-6108(02)00157-5

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title = "MMP9 potentiates pulmonary metastasis formation",

abstract = "Tumor cell dissemination to distant organ sites is a complex process involving multiple cell types, soluble growth factors, adhesion receptors, and tissue remodeling. A new study in this issue of Cancer Cell shows that MMP9-expressing tumor-associated macrophages play a key role in prepping premetastatic sites for eventual malignant cell growth in a manner dependent upon vascular endothelial growth factor receptor-1 (VEGFR-1).",

author = "{Van Kempen}, {L{\'e}on C.L.} and Coussens, {Lisa M.}",

year = "2002",

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language = "English (US)",

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T1 - MMP9 potentiates pulmonary metastasis formation

AU - Van Kempen, Léon C.L.

AU - Coussens, Lisa M.

PY - 2002/10

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N2 - Tumor cell dissemination to distant organ sites is a complex process involving multiple cell types, soluble growth factors, adhesion receptors, and tissue remodeling. A new study in this issue of Cancer Cell shows that MMP9-expressing tumor-associated macrophages play a key role in prepping premetastatic sites for eventual malignant cell growth in a manner dependent upon vascular endothelial growth factor receptor-1 (VEGFR-1).

AB - Tumor cell dissemination to distant organ sites is a complex process involving multiple cell types, soluble growth factors, adhesion receptors, and tissue remodeling. A new study in this issue of Cancer Cell shows that MMP9-expressing tumor-associated macrophages play a key role in prepping premetastatic sites for eventual malignant cell growth in a manner dependent upon vascular endothelial growth factor receptor-1 (VEGFR-1).

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U2 - 10.1016/S1535-6108(02)00157-5

DO - 10.1016/S1535-6108(02)00157-5

M3 - Review article

C2 - 12398887

AN - SCOPUS:0036781709

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VL - 2

SP - 251

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JO - Cancer Cell

JF - Cancer Cell

IS - 4

ER -

MMP9 potentiates pulmonary metastasis formation

Abstract

ASJC Scopus subject areas

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