MK801 - A neuroprotectant in rat hypertensive eyes

Priya Chaudhary, Farid Ahmed, S. C. Sharma

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

Excitatory synaptic transmission in the mammalian CNS and retina is mainly mediated through L-glutamate. The effect of MK-801, a non-competitive antagonist of the NMDA subtype of glutamate receptor was studied on rat retinal ganglion cells in hypertensive eyes. MK-801 was administered intraperitoneally to the first group, 1 day before the increase, and in the second group, 2 days after the intraocular pressure (IOP) elevation. Phosphate-buffered saline was administered to the control group. Animals were sacrifice 2 and 4 weeks post-IOP increase. The retinal ganglion cells were counted and compared between control (right) and experimental (left) eyes. The data presented here suggests that MK-801 has neuroprotective properties.

Original languageEnglish (US)
Pages (from-to)154-158
Number of pages5
JournalBrain Research
Volume792
Issue number1
DOIs
Publication statusPublished - May 4 1998
Externally publishedYes

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Keywords

  • C-fos
  • Glaucoma
  • Hypertensive eye
  • MK-801
  • NMDA receptor

ASJC Scopus subject areas

  • Neuroscience(all)

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