MK801 - A neuroprotectant in rat hypertensive eyes

Priya Chaudhary; Farid Ahmed; S. C. Sharma

doi:10.1016/S0006-8993(98)00212-1

MK801 - A neuroprotectant in rat hypertensive eyes

Priya Chaudhary, Farid Ahmed, S. C. Sharma

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

Excitatory synaptic transmission in the mammalian CNS and retina is mainly mediated through L-glutamate. The effect of MK-801, a non-competitive antagonist of the NMDA subtype of glutamate receptor was studied on rat retinal ganglion cells in hypertensive eyes. MK-801 was administered intraperitoneally to the first group, 1 day before the increase, and in the second group, 2 days after the intraocular pressure (IOP) elevation. Phosphate-buffered saline was administered to the control group. Animals were sacrifice 2 and 4 weeks post-IOP increase. The retinal ganglion cells were counted and compared between control (right) and experimental (left) eyes. The data presented here suggests that MK-801 has neuroprotective properties.

Original language	English (US)
Pages (from-to)	154-158
Number of pages	5
Journal	Brain research
Volume	792
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(98)00212-1
State	Published - May 4 1998
Externally published	Yes

Keywords

C-fos
Glaucoma
Hypertensive eye
MK-801
NMDA receptor

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(98)00212-1

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title = "MK801 - A neuroprotectant in rat hypertensive eyes",

abstract = "Excitatory synaptic transmission in the mammalian CNS and retina is mainly mediated through L-glutamate. The effect of MK-801, a non-competitive antagonist of the NMDA subtype of glutamate receptor was studied on rat retinal ganglion cells in hypertensive eyes. MK-801 was administered intraperitoneally to the first group, 1 day before the increase, and in the second group, 2 days after the intraocular pressure (IOP) elevation. Phosphate-buffered saline was administered to the control group. Animals were sacrifice 2 and 4 weeks post-IOP increase. The retinal ganglion cells were counted and compared between control (right) and experimental (left) eyes. The data presented here suggests that MK-801 has neuroprotective properties.",

keywords = "C-fos, Glaucoma, Hypertensive eye, MK-801, NMDA receptor",

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T1 - MK801 - A neuroprotectant in rat hypertensive eyes

AU - Chaudhary, Priya

AU - Ahmed, Farid

AU - Sharma, S. C.

N1 - Funding Information: This research was supported by N.I.H. Grant EY11295.

PY - 1998/5/4

Y1 - 1998/5/4

N2 - Excitatory synaptic transmission in the mammalian CNS and retina is mainly mediated through L-glutamate. The effect of MK-801, a non-competitive antagonist of the NMDA subtype of glutamate receptor was studied on rat retinal ganglion cells in hypertensive eyes. MK-801 was administered intraperitoneally to the first group, 1 day before the increase, and in the second group, 2 days after the intraocular pressure (IOP) elevation. Phosphate-buffered saline was administered to the control group. Animals were sacrifice 2 and 4 weeks post-IOP increase. The retinal ganglion cells were counted and compared between control (right) and experimental (left) eyes. The data presented here suggests that MK-801 has neuroprotective properties.

AB - Excitatory synaptic transmission in the mammalian CNS and retina is mainly mediated through L-glutamate. The effect of MK-801, a non-competitive antagonist of the NMDA subtype of glutamate receptor was studied on rat retinal ganglion cells in hypertensive eyes. MK-801 was administered intraperitoneally to the first group, 1 day before the increase, and in the second group, 2 days after the intraocular pressure (IOP) elevation. Phosphate-buffered saline was administered to the control group. Animals were sacrifice 2 and 4 weeks post-IOP increase. The retinal ganglion cells were counted and compared between control (right) and experimental (left) eyes. The data presented here suggests that MK-801 has neuroprotective properties.

KW - C-fos

KW - Glaucoma

KW - Hypertensive eye

KW - MK-801

KW - NMDA receptor

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MK801 - A neuroprotectant in rat hypertensive eyes

Abstract

Keywords

ASJC Scopus subject areas

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