MK-801, and NMDA antagonist, reduces volatile anaesthetic MAC and has haemodynamic and EEG effects in rabbits

M. S. Scheller, Mark Zornow, A. Tateishi, J. C. Drummond, J. E. Fleischer, G. T. Shearman

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

MK-801 is a central nervous system glutamate antagonist that has recently been reported to ameliorate neuronal damage in an animal model of focal cerebral ischaemia. When administered to awake rabbits and cats, MK-801 causes profound and long-lasting sedation. This suggests that MK-801 may have anaesthetic properties. In order to examine this possibility, we determined the effects of a bolus dose of MK-801 on halothane and isoflurane MAC, the electroencephalogram (EEG) and cardiovascular variables in rabbits.

Original languageEnglish (US)
JournalCanadian Journal of Anaesthesia
Volume35
Issue number3 II
StatePublished - 1988
Externally publishedYes

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Dizocilpine Maleate
N-Methylaspartate
Anesthetics
Electroencephalography
Hemodynamics
Rabbits
Excitatory Amino Acid Antagonists
Isoflurane
Halothane
Brain Ischemia
Cats
Central Nervous System
Animal Models

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Scheller, M. S., Zornow, M., Tateishi, A., Drummond, J. C., Fleischer, J. E., & Shearman, G. T. (1988). MK-801, and NMDA antagonist, reduces volatile anaesthetic MAC and has haemodynamic and EEG effects in rabbits. Canadian Journal of Anaesthesia, 35(3 II).

MK-801, and NMDA antagonist, reduces volatile anaesthetic MAC and has haemodynamic and EEG effects in rabbits. / Scheller, M. S.; Zornow, Mark; Tateishi, A.; Drummond, J. C.; Fleischer, J. E.; Shearman, G. T.

In: Canadian Journal of Anaesthesia, Vol. 35, No. 3 II, 1988.

Research output: Contribution to journalArticle

Scheller, M. S. ; Zornow, Mark ; Tateishi, A. ; Drummond, J. C. ; Fleischer, J. E. ; Shearman, G. T. / MK-801, and NMDA antagonist, reduces volatile anaesthetic MAC and has haemodynamic and EEG effects in rabbits. In: Canadian Journal of Anaesthesia. 1988 ; Vol. 35, No. 3 II.
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