MK-801 is a central nervous system glutamate antagonist that has recently been reported to ameliorate neuronal damage in an animal model of focal cerebral ischaemia. When administered to awake rabbits and cats, MK-801 causes profound and long-lasting sedation. This suggests that MK-801 may have anaesthetic properties. In order to examine this possibility, we determined the effects of a bolus dose of MK-801 on halothane and isoflurane MAC, the electroencephalogram (EEG) and cardiovascular variables in rabbits.
|Original language||English (US)|
|Journal||Canadian Journal of Anaesthesia|
|Issue number||3 II|
|State||Published - 1988|
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine