MK-801, and NMDA antagonist, reduces volatile anaesthetic MAC and has haemodynamic and EEG effects in rabbits

M. S. Scheller; M. H. Zornow; A. Tateishi; J. C. Drummond; J. E. Fleischer; G. T. Shearman

MK-801, and NMDA antagonist, reduces volatile anaesthetic MAC and has haemodynamic and EEG effects in rabbits

M. S. Scheller, M. H. Zornow, A. Tateishi, J. C. Drummond, J. E. Fleischer, G. T. Shearman

Research output: Contribution to journal › Article › peer-review

Abstract

MK-801 is a central nervous system glutamate antagonist that has recently been reported to ameliorate neuronal damage in an animal model of focal cerebral ischaemia. When administered to awake rabbits and cats, MK-801 causes profound and long-lasting sedation. This suggests that MK-801 may have anaesthetic properties. In order to examine this possibility, we determined the effects of a bolus dose of MK-801 on halothane and isoflurane MAC, the electroencephalogram (EEG) and cardiovascular variables in rabbits.

Original language	English (US)
Pages (from-to)	S96-S97
Journal	Canadian Journal of Anaesthesia
Volume	35
Issue number	3 II
State	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

Anesthesiology and Pain Medicine

Cite this

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AU - Scheller, M. S.

AU - Zornow, M. H.

AU - Tateishi, A.

AU - Drummond, J. C.

AU - Fleischer, J. E.

AU - Shearman, G. T.

PY - 1988

Y1 - 1988

N2 - MK-801 is a central nervous system glutamate antagonist that has recently been reported to ameliorate neuronal damage in an animal model of focal cerebral ischaemia. When administered to awake rabbits and cats, MK-801 causes profound and long-lasting sedation. This suggests that MK-801 may have anaesthetic properties. In order to examine this possibility, we determined the effects of a bolus dose of MK-801 on halothane and isoflurane MAC, the electroencephalogram (EEG) and cardiovascular variables in rabbits.

AB - MK-801 is a central nervous system glutamate antagonist that has recently been reported to ameliorate neuronal damage in an animal model of focal cerebral ischaemia. When administered to awake rabbits and cats, MK-801 causes profound and long-lasting sedation. This suggests that MK-801 may have anaesthetic properties. In order to examine this possibility, we determined the effects of a bolus dose of MK-801 on halothane and isoflurane MAC, the electroencephalogram (EEG) and cardiovascular variables in rabbits.

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IS - 3 II

ER -

MK-801, and NMDA antagonist, reduces volatile anaesthetic MAC and has haemodynamic and EEG effects in rabbits

Abstract

ASJC Scopus subject areas

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