Mixed connective tissue disease: clinical and radiological aspects of 20 cases

D. J. O'Connell, R. M. Bennett

    Research output: Contribution to journalArticle

    35 Scopus citations


    The clinical and radiological features of 20 cases of mixed connective tissue disease (MCTD), a newly defined disorder, are described. MCTD shares a number of abnormalities with other collagen diseases, notably diffuse systemic sclerosis and systemic lupus erythematosus. However, patients with MCTD have a specific circulating antibody to extractable nuclear antigen (ENA). Most of the cases described exhibited multi-system involvement with radiological changes in the skeleton, chest, and gastro-intestinal tract. Twelve of the 20 cases had an erosive arthritis. This finding has not been previously noted in the radiological literature.

    Original languageEnglish (US)
    Pages (from-to)620-625
    Number of pages6
    JournalBritish Journal of Radiology
    Issue number597
    StatePublished - Jan 1 1977


    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging

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