TY - JOUR
T1 - Mixed connective tissue disease
T2 - clinical and radiological aspects of 20 cases
AU - O'Connell, D. J.
AU - Bennett, R. M.
PY - 1977/1/1
Y1 - 1977/1/1
N2 - The clinical and radiological features of 20 cases of mixed connective tissue disease (MCTD), a newly defined disorder, are described. MCTD shares a number of abnormalities with other collagen diseases, notably diffuse systemic sclerosis and systemic lupus erythematosus. However, patients with MCTD have a specific circulating antibody to extractable nuclear antigen (ENA). Most of the cases described exhibited multi-system involvement with radiological changes in the skeleton, chest, and gastro-intestinal tract. Twelve of the 20 cases had an erosive arthritis. This finding has not been previously noted in the radiological literature.
AB - The clinical and radiological features of 20 cases of mixed connective tissue disease (MCTD), a newly defined disorder, are described. MCTD shares a number of abnormalities with other collagen diseases, notably diffuse systemic sclerosis and systemic lupus erythematosus. However, patients with MCTD have a specific circulating antibody to extractable nuclear antigen (ENA). Most of the cases described exhibited multi-system involvement with radiological changes in the skeleton, chest, and gastro-intestinal tract. Twelve of the 20 cases had an erosive arthritis. This finding has not been previously noted in the radiological literature.
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U2 - 10.1259/0007-1285-50-597-620
DO - 10.1259/0007-1285-50-597-620
M3 - Article
C2 - 901973
AN - SCOPUS:0017691581
SN - 0007-1285
VL - 50
SP - 620
EP - 625
JO - British Journal of Radiology
JF - British Journal of Radiology
IS - 597
ER -