Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions

Gray Pearson, Fred Robinson, Tara Beers Gibson, Bing E. Xu, Mahesh Karandikar, Kevin Berman, Melanie H. Cobb

Research output: Contribution to journalReview article

3173 Scopus citations

Abstract

Mitogen-activated protein (MAP) kinases comprise a family of ubiquitous proline-directed, protein-serine/threonine kinases, which participate in signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms. MAP kinases lie in protein kinase cascades. This review discusses the regulation and functions of mammalian MAP kinases. Nonenzymatic mechanisms that impact MAP kinase functions and findings from gene disruption studies are highlighted. Particular emphasis is on ERK1/2.

Original languageEnglish (US)
Pages (from-to)153-183
Number of pages31
JournalEndocrine reviews
Volume22
Issue number2
DOIs
StatePublished - May 31 2001

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Fingerprint Dive into the research topics of 'Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions'. Together they form a unique fingerprint.

  • Cite this

    Pearson, G., Robinson, F., Gibson, T. B., Xu, B. E., Karandikar, M., Berman, K., & Cobb, M. H. (2001). Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions. Endocrine reviews, 22(2), 153-183. https://doi.org/10.1210/er.22.2.153