Mitochondrial MicroRNAs in Aging and Neurodegenerative Diseases

Albin John; Aaron Kubosumi; P. Hemachandra Reddy

doi:10.3390/cells9061345

Mitochondrial MicroRNAs in Aging and Neurodegenerative Diseases

Albin John, Aaron Kubosumi, P. Hemachandra Reddy

Research output: Contribution to journal › Review article

Abstract

MicroRNAs (miRNAs) are important regulators of several biological processes, such as cell growth, cell proliferation, embryonic development, tissue differentiation, and apoptosis. Currently, over 2000 mammalian miRNAs have been reported to regulate these biological processes. A subset of microRNAs was found to be localized to human mitochondria (mitomiRs). Through years of research, over 400 mitomiRs have been shown to modulate the translational activity of the mitochondrial genome. While miRNAs have been studied for years, the function of mitomiRs and their role in neurodegenerative pathologies is not known. The purpose of our article is to highlight recent findings that relate mitomiRs to neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's. We also discuss the involvement of mitomiRs in regulating the mitochondrial genome in age-related neurodegenerative diseases.

Original language	English (US)
Journal	Cells
Volume	9
Issue number	6
DOIs	https://doi.org/10.3390/cells9061345
State	Published - May 28 2020

Keywords

aging
Alzheimer’s disease
Huntington’s disease
microRNAs
mitochondrial function and mitophagy
mitochondrial microRNAs
oxidative stress
Parkinson’s disease

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10.3390/cells9061345

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John, A., Kubosumi, A., & Reddy, P. H. (2020). Mitochondrial MicroRNAs in Aging and Neurodegenerative Diseases. Cells, 9(6). https://doi.org/10.3390/cells9061345

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abstract = "MicroRNAs (miRNAs) are important regulators of several biological processes, such as cell growth, cell proliferation, embryonic development, tissue differentiation, and apoptosis. Currently, over 2000 mammalian miRNAs have been reported to regulate these biological processes. A subset of microRNAs was found to be localized to human mitochondria (mitomiRs). Through years of research, over 400 mitomiRs have been shown to modulate the translational activity of the mitochondrial genome. While miRNAs have been studied for years, the function of mitomiRs and their role in neurodegenerative pathologies is not known. The purpose of our article is to highlight recent findings that relate mitomiRs to neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's. We also discuss the involvement of mitomiRs in regulating the mitochondrial genome in age-related neurodegenerative diseases.",

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N2 - MicroRNAs (miRNAs) are important regulators of several biological processes, such as cell growth, cell proliferation, embryonic development, tissue differentiation, and apoptosis. Currently, over 2000 mammalian miRNAs have been reported to regulate these biological processes. A subset of microRNAs was found to be localized to human mitochondria (mitomiRs). Through years of research, over 400 mitomiRs have been shown to modulate the translational activity of the mitochondrial genome. While miRNAs have been studied for years, the function of mitomiRs and their role in neurodegenerative pathologies is not known. The purpose of our article is to highlight recent findings that relate mitomiRs to neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's. We also discuss the involvement of mitomiRs in regulating the mitochondrial genome in age-related neurodegenerative diseases.

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KW - Parkinson’s disease

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