TY - JOUR
T1 - Mitochondrial MicroRNAs in Aging and Neurodegenerative Diseases
AU - John, Albin
AU - Kubosumi, Aaron
AU - Reddy, P. Hemachandra
N1 - Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 2020/5/28
Y1 - 2020/5/28
N2 - MicroRNAs (miRNAs) are important regulators of several biological processes, such as cell growth, cell proliferation, embryonic development, tissue differentiation, and apoptosis. Currently, over 2000 mammalian miRNAs have been reported to regulate these biological processes. A subset of microRNAs was found to be localized to human mitochondria (mitomiRs). Through years of research, over 400 mitomiRs have been shown to modulate the translational activity of the mitochondrial genome. While miRNAs have been studied for years, the function of mitomiRs and their role in neurodegenerative pathologies is not known. The purpose of our article is to highlight recent findings that relate mitomiRs to neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's. We also discuss the involvement of mitomiRs in regulating the mitochondrial genome in age-related neurodegenerative diseases.
AB - MicroRNAs (miRNAs) are important regulators of several biological processes, such as cell growth, cell proliferation, embryonic development, tissue differentiation, and apoptosis. Currently, over 2000 mammalian miRNAs have been reported to regulate these biological processes. A subset of microRNAs was found to be localized to human mitochondria (mitomiRs). Through years of research, over 400 mitomiRs have been shown to modulate the translational activity of the mitochondrial genome. While miRNAs have been studied for years, the function of mitomiRs and their role in neurodegenerative pathologies is not known. The purpose of our article is to highlight recent findings that relate mitomiRs to neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's. We also discuss the involvement of mitomiRs in regulating the mitochondrial genome in age-related neurodegenerative diseases.
KW - Alzheimer’s disease
KW - Huntington’s disease
KW - Parkinson’s disease
KW - aging
KW - microRNAs
KW - mitochondrial function and mitophagy
KW - mitochondrial microRNAs
KW - oxidative stress
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U2 - 10.3390/cells9061345
DO - 10.3390/cells9061345
M3 - Review article
C2 - 32481587
AN - SCOPUS:85085676115
VL - 9
JO - Cells
JF - Cells
SN - 2073-4409
IS - 6
ER -