Mitochondrial MicroRNAs in Aging and Neurodegenerative Diseases

Albin John, Aaron Kubosumi, P. Hemachandra Reddy

    Research output: Contribution to journalReview article

    Abstract

    MicroRNAs (miRNAs) are important regulators of several biological processes, such as cell growth, cell proliferation, embryonic development, tissue differentiation, and apoptosis. Currently, over 2000 mammalian miRNAs have been reported to regulate these biological processes. A subset of microRNAs was found to be localized to human mitochondria (mitomiRs). Through years of research, over 400 mitomiRs have been shown to modulate the translational activity of the mitochondrial genome. While miRNAs have been studied for years, the function of mitomiRs and their role in neurodegenerative pathologies is not known. The purpose of our article is to highlight recent findings that relate mitomiRs to neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's. We also discuss the involvement of mitomiRs in regulating the mitochondrial genome in age-related neurodegenerative diseases.

    Original languageEnglish (US)
    JournalCells
    Volume9
    Issue number6
    DOIs
    StatePublished - May 28 2020

    Keywords

    • aging
    • Alzheimer’s disease
    • Huntington’s disease
    • microRNAs
    • mitochondrial function and mitophagy
    • mitochondrial microRNAs
    • oxidative stress
    • Parkinson’s disease

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