Mitochondrial division and fusion in metabolism

Madhuparna Roy, P. Hemachandra Reddy, Miho Iijima, Hiromi Sesaki

    Research output: Contribution to journalReview articlepeer-review

    102 Scopus citations

    Abstract

    Mitochondria govern many metabolic processes. In addition, mitochondria sense the status of metabolism and change their functions to regulate energy production, cell death, and thermogenesis. Recent studies have revealed that mitochondrial structural remodeling through division and fusion is critical to the organelle's function. It has also become clear that abnormalities in mitochondrial division and fusion are linked to the pathophysiology of metabolic diseases such as diabetes and obesity. Here, we discuss the current understanding of the mechanisms of mitochondrial dynamics and their role in cellular and organismal metabolism.

    Original languageEnglish (US)
    Pages (from-to)111-118
    Number of pages8
    JournalCurrent Opinion in Cell Biology
    Volume33
    DOIs
    StatePublished - Apr 1 2015

    ASJC Scopus subject areas

    • Cell Biology

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