Mitochondria in pluripotent stem cells: Stemness regulators and disease targets

Clifford D.L. Folmes, Hong Ma, Shoukhrat Mitalipov, Andre Terzic

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

Beyond their canonical role in efficient ATP production through oxidative metabolism, mitochondria are increasingly recognized as critical in defining stem cell function and fate. Implicating a fundamental interplay within the epigenetics of eukaryotic cell systems, the integrity of mitochondria is found vital across the developmental/differentiation spectrum from securing pluripotency maintenance to informing organotypic decisions. This overview will discuss recent progress on examining the plasticity of mitochondria in enabling the execution of programming and reprogramming regimens, as well as the application of nuclear reprogramming and somatic cell nuclear transfer as rescue techniques to generate genetically and functionally corrected pluripotent stem cells from patients with mitochondrial DNA-based disease.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalCurrent Opinion in Genetics and Development
Volume38
DOIs
StatePublished - Jun 1 2016

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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