Abstract
Background: H2O2 mediates signal transduction in response to TCR activation. Results: Overexpressing mitochondrial Mn-SOD increases H2O2, enhancing intensity and duration of tyrosine phosphorylation after TCR activation, whereas overexpressing cytosolic Cu,Zn-SOD has no effect. Conclusion: Mitochondrial H2O2 enhances TCR-mediated signal transduction selectively through JNK/cJun. Significance: Mitochondrial translocation to the immunological synapse provides necessary proximity to raise effective H2O2 concentration to modulate TCR signaling.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 26246-26255 |
| Number of pages | 10 |
| Journal | Journal of Biological Chemistry |
| Volume | 288 |
| Issue number | 36 |
| DOIs | |
| State | Published - Sep 6 2013 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology