Background: H2O2 mediates signal transduction in response to TCR activation. Results: Overexpressing mitochondrial Mn-SOD increases H2O2, enhancing intensity and duration of tyrosine phosphorylation after TCR activation, whereas overexpressing cytosolic Cu,Zn-SOD has no effect. Conclusion: Mitochondrial H2O2 enhances TCR-mediated signal transduction selectively through JNK/cJun. Significance: Mitochondrial translocation to the immunological synapse provides necessary proximity to raise effective H2O2 concentration to modulate TCR signaling.
|Original language||English (US)|
|Number of pages||10|
|Journal||Journal of Biological Chemistry|
|State||Published - Sep 6 2013|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology