Mitochondria-derived hydrogen peroxide selectively enhances T cell receptor-initiated signal transduction

Tejpal Gill, Alan D. Levine

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Background: H2O2 mediates signal transduction in response to TCR activation. Results: Overexpressing mitochondrial Mn-SOD increases H2O2, enhancing intensity and duration of tyrosine phosphorylation after TCR activation, whereas overexpressing cytosolic Cu,Zn-SOD has no effect. Conclusion: Mitochondrial H2O2 enhances TCR-mediated signal transduction selectively through JNK/cJun. Significance: Mitochondrial translocation to the immunological synapse provides necessary proximity to raise effective H2O2 concentration to modulate TCR signaling.

Original languageEnglish (US)
Pages (from-to)26246-26255
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number36
DOIs
StatePublished - Sep 6 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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