Mitochondria as a therapeutic target for aging and neurodegenerative diseases

P (Hemachandra) Reddy, T. P. Reddy

    Research output: Contribution to journalArticle

    110 Citations (Scopus)

    Abstract

    Mitochondria are cytoplasmic organelles responsible for life and death. Extensive evidence from animal models, postmortem brain studies of and clinical studies of aging and neurodegenerative diseases suggests that mitochondrial function is defective in aging and neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. Several lines of research suggest that mitochondrial abnormalities, including defects in oxidative phosphorylation, increased accumulation of mitochondrial DNA defects, impaired calcium influx, accumulation of mutant proteins in mitochondria, and mitochondrial membrane potential dissipation are important cellular changes in both early and late-onset neurodegenerative diseases. Further, emerging evidence suggests that structural changes in mitochondria, including increased mitochondrial fragmentation and decreased mitochondrial fusion, are critical factors associated with mitochondrial dysfunction and cell death in aging and neurodegenerative diseases. This paper discusses research that elucidates features of mitochondria that are associated with cellular dysfunction in aging and neurodegenerative diseases and discusses mitochondrial structural and functional changes, and abnormal mitochondrial dynamics in neurodegenerative diseases. It also outlines mitochondria-targeted therapeutics in neurodegenerative diseases.

    Original languageEnglish (US)
    Pages (from-to)393-409
    Number of pages17
    JournalCurrent Alzheimer Research
    Volume8
    Issue number4
    DOIs
    StatePublished - Jun 2011

    Fingerprint

    Neurodegenerative Diseases
    Mitochondria
    Mitochondrial Dynamics
    Therapeutics
    Mitochondrial Membrane Potential
    Huntington Disease
    Oxidative Phosphorylation
    Amyotrophic Lateral Sclerosis
    Mutant Proteins
    Mitochondrial DNA
    Research
    Organelles
    Parkinson Disease
    Alzheimer Disease
    Cell Death
    Animal Models
    Calcium
    Brain

    Keywords

    • Abnormal mitochondrial dynamics
    • Aging
    • Alzheimer's disease
    • Huntington's disease
    • Mitochondria
    • Mitochondria-targeted antioxidants
    • Neurodegenerative disease
    • Parkinson's disease

    ASJC Scopus subject areas

    • Neurology
    • Clinical Neurology

    Cite this

    Mitochondria as a therapeutic target for aging and neurodegenerative diseases. / Reddy, P (Hemachandra); Reddy, T. P.

    In: Current Alzheimer Research, Vol. 8, No. 4, 06.2011, p. 393-409.

    Research output: Contribution to journalArticle

    Reddy, P (Hemachandra) ; Reddy, T. P. / Mitochondria as a therapeutic target for aging and neurodegenerative diseases. In: Current Alzheimer Research. 2011 ; Vol. 8, No. 4. pp. 393-409.
    @article{35202ed83de64e569565a12c9235359f,
    title = "Mitochondria as a therapeutic target for aging and neurodegenerative diseases",
    abstract = "Mitochondria are cytoplasmic organelles responsible for life and death. Extensive evidence from animal models, postmortem brain studies of and clinical studies of aging and neurodegenerative diseases suggests that mitochondrial function is defective in aging and neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. Several lines of research suggest that mitochondrial abnormalities, including defects in oxidative phosphorylation, increased accumulation of mitochondrial DNA defects, impaired calcium influx, accumulation of mutant proteins in mitochondria, and mitochondrial membrane potential dissipation are important cellular changes in both early and late-onset neurodegenerative diseases. Further, emerging evidence suggests that structural changes in mitochondria, including increased mitochondrial fragmentation and decreased mitochondrial fusion, are critical factors associated with mitochondrial dysfunction and cell death in aging and neurodegenerative diseases. This paper discusses research that elucidates features of mitochondria that are associated with cellular dysfunction in aging and neurodegenerative diseases and discusses mitochondrial structural and functional changes, and abnormal mitochondrial dynamics in neurodegenerative diseases. It also outlines mitochondria-targeted therapeutics in neurodegenerative diseases.",
    keywords = "Abnormal mitochondrial dynamics, Aging, Alzheimer's disease, Huntington's disease, Mitochondria, Mitochondria-targeted antioxidants, Neurodegenerative disease, Parkinson's disease",
    author = "Reddy, {P (Hemachandra)} and Reddy, {T. P.}",
    year = "2011",
    month = "6",
    doi = "10.2174/156720511795745401",
    language = "English (US)",
    volume = "8",
    pages = "393--409",
    journal = "Current Alzheimer Research",
    issn = "1567-2050",
    publisher = "Bentham Science Publishers B.V.",
    number = "4",

    }

    TY - JOUR

    T1 - Mitochondria as a therapeutic target for aging and neurodegenerative diseases

    AU - Reddy, P (Hemachandra)

    AU - Reddy, T. P.

    PY - 2011/6

    Y1 - 2011/6

    N2 - Mitochondria are cytoplasmic organelles responsible for life and death. Extensive evidence from animal models, postmortem brain studies of and clinical studies of aging and neurodegenerative diseases suggests that mitochondrial function is defective in aging and neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. Several lines of research suggest that mitochondrial abnormalities, including defects in oxidative phosphorylation, increased accumulation of mitochondrial DNA defects, impaired calcium influx, accumulation of mutant proteins in mitochondria, and mitochondrial membrane potential dissipation are important cellular changes in both early and late-onset neurodegenerative diseases. Further, emerging evidence suggests that structural changes in mitochondria, including increased mitochondrial fragmentation and decreased mitochondrial fusion, are critical factors associated with mitochondrial dysfunction and cell death in aging and neurodegenerative diseases. This paper discusses research that elucidates features of mitochondria that are associated with cellular dysfunction in aging and neurodegenerative diseases and discusses mitochondrial structural and functional changes, and abnormal mitochondrial dynamics in neurodegenerative diseases. It also outlines mitochondria-targeted therapeutics in neurodegenerative diseases.

    AB - Mitochondria are cytoplasmic organelles responsible for life and death. Extensive evidence from animal models, postmortem brain studies of and clinical studies of aging and neurodegenerative diseases suggests that mitochondrial function is defective in aging and neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. Several lines of research suggest that mitochondrial abnormalities, including defects in oxidative phosphorylation, increased accumulation of mitochondrial DNA defects, impaired calcium influx, accumulation of mutant proteins in mitochondria, and mitochondrial membrane potential dissipation are important cellular changes in both early and late-onset neurodegenerative diseases. Further, emerging evidence suggests that structural changes in mitochondria, including increased mitochondrial fragmentation and decreased mitochondrial fusion, are critical factors associated with mitochondrial dysfunction and cell death in aging and neurodegenerative diseases. This paper discusses research that elucidates features of mitochondria that are associated with cellular dysfunction in aging and neurodegenerative diseases and discusses mitochondrial structural and functional changes, and abnormal mitochondrial dynamics in neurodegenerative diseases. It also outlines mitochondria-targeted therapeutics in neurodegenerative diseases.

    KW - Abnormal mitochondrial dynamics

    KW - Aging

    KW - Alzheimer's disease

    KW - Huntington's disease

    KW - Mitochondria

    KW - Mitochondria-targeted antioxidants

    KW - Neurodegenerative disease

    KW - Parkinson's disease

    UR - http://www.scopus.com/inward/record.url?scp=79959344446&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=79959344446&partnerID=8YFLogxK

    U2 - 10.2174/156720511795745401

    DO - 10.2174/156720511795745401

    M3 - Article

    VL - 8

    SP - 393

    EP - 409

    JO - Current Alzheimer Research

    JF - Current Alzheimer Research

    SN - 1567-2050

    IS - 4

    ER -