Mismatch induced speciation in Salmonella

Model and data

Daniel Falush, Mia Torpdahl, Xavier Didelot, Don Conrad, Daniel J. Wilson, Mark Achtman

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

In bacteria, DNA sequence mismatches act as a barrier to recombination between distantly related organisms and can potentially promote the cohesion of species. We have performed computer simulations which show that the homology dependence of recombination can cause de novo speciation in a neutrally evolving population once a critical population size has been exceeded. Our model can explain the patterns of divergence and genetic exchange observed in the genus Salmonella, without invoking either natural selection or geographical population subdivision. If this model was validated, based on extensive sequence data, it would imply that the named subspecies of Salmonella enterica correspond to good biological species, making species boundaries objective. However, multilocus sequence typing data, analysed using several conventional tools, provide a misleading impression of relationships within S. enterica subspecies enterica and do not provide the resolution to establish whether new species are presently being formed.

Original languageEnglish (US)
Pages (from-to)2045-2053
Number of pages9
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume361
Issue number1475
DOIs
StatePublished - Nov 29 2006
Externally publishedYes

Fingerprint

Salmonella
Salmonella enterica
Genetic Recombination
Multilocus Sequence Typing
Genetic Selection
DNA sequences
founder effect
Population Density
cohesion
computer simulation
Computer Simulation
Population
natural selection
Bacteria
population size
nucleotide sequences
new species
bacteria
organisms
Computer simulation

Keywords

  • Genomics
  • Homology-dependent recombination
  • Mismatch repair
  • Rational systematics
  • Recombination

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Mismatch induced speciation in Salmonella : Model and data. / Falush, Daniel; Torpdahl, Mia; Didelot, Xavier; Conrad, Don; Wilson, Daniel J.; Achtman, Mark.

In: Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 361, No. 1475, 29.11.2006, p. 2045-2053.

Research output: Contribution to journalArticle

Falush, Daniel ; Torpdahl, Mia ; Didelot, Xavier ; Conrad, Don ; Wilson, Daniel J. ; Achtman, Mark. / Mismatch induced speciation in Salmonella : Model and data. In: Philosophical Transactions of the Royal Society B: Biological Sciences. 2006 ; Vol. 361, No. 1475. pp. 2045-2053.
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