Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates

Dawn M. Dudley, Koen K. Van Rompay, Lark L. Coffey, Amir Ardeshir, Rebekah I. Keesler, Eliza Bliss-Moreau, Peta Grigsby, Rosemary J. Steinbach, Alec Hirsch, Rhonda MacAllister, Heidi L. Pecoraro, Lois Colgin, Travis Hodge, Daniel Streblow, Suzette Tardif, Jean L. Patterson, Manasi Tamhankar, Maxim Seferovic, Kjersti M. Aagaard, Claudia Sánchez San Martín & 18 others Charles Y. Chiu, Antonito T. Panganiban, Ronald S. Veazey, Xiaolei Wang, Nicholas J. Maness, Margaret H. Gilbert, Rudolf P. Bohm, Kristina M. Adams Waldorf, Michael Gale, Lakshmi Rajagopal, Charlotte E. Hotchkiss, Emma L. Mohr, Saverio V. Capuano, Heather A. Simmons, Andres Mejia, Thomas C. Friedrich, Thaddeus G. Golos, David H. O’Connor

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Zika virus (ZIKV) infection is associated with congenital defects and pregnancy loss. Here, we found that 26% of nonhuman primates infected with Asian/American ZIKV in early gestation experienced fetal demise later in pregnancy despite showing few clinical signs of infection. Pregnancy loss due to asymptomatic ZIKV infection may therefore be a common but under-recognized adverse outcome related to maternal ZIKV infection.

Original languageEnglish (US)
Pages (from-to)1104-1107
Number of pages4
JournalNature Medicine
Volume24
Issue number8
DOIs
StatePublished - Aug 1 2018

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Stillbirth
Spontaneous Abortion
Viruses
Primates
Mothers
Pregnancy
Fetal Death
Asian Americans
Defects
Zika Virus Infection
Infection

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Dudley, D. M., Van Rompay, K. K., Coffey, L. L., Ardeshir, A., Keesler, R. I., Bliss-Moreau, E., ... O’Connor, D. H. (2018). Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates. Nature Medicine, 24(8), 1104-1107. https://doi.org/10.1038/s41591-018-0088-5

Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates. / Dudley, Dawn M.; Van Rompay, Koen K.; Coffey, Lark L.; Ardeshir, Amir; Keesler, Rebekah I.; Bliss-Moreau, Eliza; Grigsby, Peta; Steinbach, Rosemary J.; Hirsch, Alec; MacAllister, Rhonda; Pecoraro, Heidi L.; Colgin, Lois; Hodge, Travis; Streblow, Daniel; Tardif, Suzette; Patterson, Jean L.; Tamhankar, Manasi; Seferovic, Maxim; Aagaard, Kjersti M.; Martín, Claudia Sánchez San; Chiu, Charles Y.; Panganiban, Antonito T.; Veazey, Ronald S.; Wang, Xiaolei; Maness, Nicholas J.; Gilbert, Margaret H.; Bohm, Rudolf P.; Adams Waldorf, Kristina M.; Gale, Michael; Rajagopal, Lakshmi; Hotchkiss, Charlotte E.; Mohr, Emma L.; Capuano, Saverio V.; Simmons, Heather A.; Mejia, Andres; Friedrich, Thomas C.; Golos, Thaddeus G.; O’Connor, David H.

In: Nature Medicine, Vol. 24, No. 8, 01.08.2018, p. 1104-1107.

Research output: Contribution to journalArticle

Dudley, DM, Van Rompay, KK, Coffey, LL, Ardeshir, A, Keesler, RI, Bliss-Moreau, E, Grigsby, P, Steinbach, RJ, Hirsch, A, MacAllister, R, Pecoraro, HL, Colgin, L, Hodge, T, Streblow, D, Tardif, S, Patterson, JL, Tamhankar, M, Seferovic, M, Aagaard, KM, Martín, CSS, Chiu, CY, Panganiban, AT, Veazey, RS, Wang, X, Maness, NJ, Gilbert, MH, Bohm, RP, Adams Waldorf, KM, Gale, M, Rajagopal, L, Hotchkiss, CE, Mohr, EL, Capuano, SV, Simmons, HA, Mejia, A, Friedrich, TC, Golos, TG & O’Connor, DH 2018, 'Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates', Nature Medicine, vol. 24, no. 8, pp. 1104-1107. https://doi.org/10.1038/s41591-018-0088-5
Dudley DM, Van Rompay KK, Coffey LL, Ardeshir A, Keesler RI, Bliss-Moreau E et al. Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates. Nature Medicine. 2018 Aug 1;24(8):1104-1107. https://doi.org/10.1038/s41591-018-0088-5
Dudley, Dawn M. ; Van Rompay, Koen K. ; Coffey, Lark L. ; Ardeshir, Amir ; Keesler, Rebekah I. ; Bliss-Moreau, Eliza ; Grigsby, Peta ; Steinbach, Rosemary J. ; Hirsch, Alec ; MacAllister, Rhonda ; Pecoraro, Heidi L. ; Colgin, Lois ; Hodge, Travis ; Streblow, Daniel ; Tardif, Suzette ; Patterson, Jean L. ; Tamhankar, Manasi ; Seferovic, Maxim ; Aagaard, Kjersti M. ; Martín, Claudia Sánchez San ; Chiu, Charles Y. ; Panganiban, Antonito T. ; Veazey, Ronald S. ; Wang, Xiaolei ; Maness, Nicholas J. ; Gilbert, Margaret H. ; Bohm, Rudolf P. ; Adams Waldorf, Kristina M. ; Gale, Michael ; Rajagopal, Lakshmi ; Hotchkiss, Charlotte E. ; Mohr, Emma L. ; Capuano, Saverio V. ; Simmons, Heather A. ; Mejia, Andres ; Friedrich, Thomas C. ; Golos, Thaddeus G. ; O’Connor, David H. / Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates. In: Nature Medicine. 2018 ; Vol. 24, No. 8. pp. 1104-1107.
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