Mir-155, a central modulator of T-cell responses

Evan Lind, Pamela S. Ohashi

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The activation of T cells is a tightly regulated process that has evolved to maximize protective immune responses to pathogens while minimizing damage to self-tissues. A delicate balance of cell-intrinsic, costimulatory, and transcriptional pathways as well as micro-environmental cues such as local cytokines controls the magnitude and nature of T-cell responses in vivo. The discovery of functional small noncoding RNAs called micro-RNAs (miRNAs) has introduced new mechanisms that contribute to the regulation of protein translation and cellular responses to stimuli. miRNAs are short (approximately 22 bp) RNA species, which bind to mRNAs and suppress translation. Due to their short length and imperfect base pairing requirements, each miRNA has the potential to regulate various pathways through the translational inhibition of multiple mRNAs. The human and mouse genomes each encode hundreds of miRNAs, and studying the function of miRNAs has led to the realization that they play important roles in diverse biological processes from development and cancer to immunity. This review focuses on the function of mir-155 in T cells and the impact of this miRNA on autoimmunity, tumor immunity, and pathogen-induced immunity.

Original languageEnglish (US)
Pages (from-to)11-15
Number of pages5
JournalEuropean Journal of Immunology
Volume44
Issue number1
DOIs
StatePublished - Jan 2014
Externally publishedYes

Fingerprint

MicroRNAs
T-Lymphocytes
Immunity
Protein Biosynthesis
Biological Phenomena
Small Untranslated RNA
Human Genome
Autoimmunity
Base Pairing
Cues
Neoplasms
RNA
Cytokines
Messenger RNA

Keywords

  • CD8 T cells
  • Cellular activation
  • Immune responses
  • Mir-155

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Mir-155, a central modulator of T-cell responses. / Lind, Evan; Ohashi, Pamela S.

In: European Journal of Immunology, Vol. 44, No. 1, 01.2014, p. 11-15.

Research output: Contribution to journalArticle

Lind, Evan ; Ohashi, Pamela S. / Mir-155, a central modulator of T-cell responses. In: European Journal of Immunology. 2014 ; Vol. 44, No. 1. pp. 11-15.
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