Miotic effect of brimonidine tartrate 0.15% ophthalmic solution in normal eyes

John E. Thordsen, Kraig S. Bower, Brent B. Warren, Richard Stutzman

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Purpose: To evaluate the effect of brimonidine tartrate 0.15% ophthalmic solution (Alphagan® P) on pupil diameter in eyes of healthy adults under different luminance conditions. Setting: Center for Refractive Surgery, Ophthalmology Service, Department of Surgery, Walter Reed Army Medical Center, Washington, DC, USA. Methods: Using a Colvard pupillometer, the pupil diameter was measured in 15 eyes of 15 healthy adults under 3 luminance conditions (scotopic, mesopic, photopic). The luminance of the room was measured using the Minolta LS-110 Luminance Meter. Pupil diameter was remeasured using the same technique 30 minutes, 4 hours, and 6 hours after administration of 1 drop of brimonidine tartrate 0.15% ophthalmic solution. Results: Under scotopic conditions (luminance 0.0 candelas [cd]/m2), the pupil diameter decreased by 1.0 mm or more in 100%, 87%, and 60% of eyes at 30 minutes, 4 hours, and 6 hours, respectively (P<.005); under mesopic conditions (luminance 0.2 cd/m2), in 93%, 73%, and 40% of eyes, respectively (P<.005); and under photopic conditions (luminance 150.2 cd/m2), in 73%, 87%, and 67% of eyes, respectively (P<.005). Conclusions: Brimonidine tartrate 0.15% ophthalmic solution produced a significant miotic effect under all 3 luminance conditions. The reproducible miotic effect under scotopic and mesopic conditions may help postoperative refractive patients who report night-vision difficulties related to a large pupil.

Original languageEnglish (US)
Pages (from-to)1702-1706
Number of pages5
JournalJournal of cataract and refractive surgery
Volume30
Issue number8
DOIs
StatePublished - Aug 1 2004
Externally publishedYes

Fingerprint

Miotics
Ophthalmic Solutions
Pupil
Night Vision
Refractive Surgical Procedures
Ophthalmology
Brimonidine Tartrate

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology
  • Sensory Systems

Cite this

Miotic effect of brimonidine tartrate 0.15% ophthalmic solution in normal eyes. / Thordsen, John E.; Bower, Kraig S.; Warren, Brent B.; Stutzman, Richard.

In: Journal of cataract and refractive surgery, Vol. 30, No. 8, 01.08.2004, p. 1702-1706.

Research output: Contribution to journalArticle

Thordsen, John E. ; Bower, Kraig S. ; Warren, Brent B. ; Stutzman, Richard. / Miotic effect of brimonidine tartrate 0.15% ophthalmic solution in normal eyes. In: Journal of cataract and refractive surgery. 2004 ; Vol. 30, No. 8. pp. 1702-1706.
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abstract = "Purpose: To evaluate the effect of brimonidine tartrate 0.15{\%} ophthalmic solution (Alphagan{\circledR} P) on pupil diameter in eyes of healthy adults under different luminance conditions. Setting: Center for Refractive Surgery, Ophthalmology Service, Department of Surgery, Walter Reed Army Medical Center, Washington, DC, USA. Methods: Using a Colvard pupillometer, the pupil diameter was measured in 15 eyes of 15 healthy adults under 3 luminance conditions (scotopic, mesopic, photopic). The luminance of the room was measured using the Minolta LS-110 Luminance Meter. Pupil diameter was remeasured using the same technique 30 minutes, 4 hours, and 6 hours after administration of 1 drop of brimonidine tartrate 0.15{\%} ophthalmic solution. Results: Under scotopic conditions (luminance 0.0 candelas [cd]/m2), the pupil diameter decreased by 1.0 mm or more in 100{\%}, 87{\%}, and 60{\%} of eyes at 30 minutes, 4 hours, and 6 hours, respectively (P<.005); under mesopic conditions (luminance 0.2 cd/m2), in 93{\%}, 73{\%}, and 40{\%} of eyes, respectively (P<.005); and under photopic conditions (luminance 150.2 cd/m2), in 73{\%}, 87{\%}, and 67{\%} of eyes, respectively (P<.005). Conclusions: Brimonidine tartrate 0.15{\%} ophthalmic solution produced a significant miotic effect under all 3 luminance conditions. The reproducible miotic effect under scotopic and mesopic conditions may help postoperative refractive patients who report night-vision difficulties related to a large pupil.",
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