TY - JOUR
T1 - Minocycline-induced scleral pigmentation
AU - Fraunfelder, F. T.
AU - Randall, J. A.
N1 - Funding Information:
Originally received: September 24, 1996. Revision accepted: February 5, 1997. From the Department of Ophthalmology, Casey Eye Institute, Oregon Health Sciences University, Portland, Oregon. Supported in part by an unrestricted grant from Research to Prevent Blindness, New York, New York. Reprint requests to Frederick T. Fraunfelder, MD, Casey Eye Institute, 3375 SW Terwilliger Boulevard, Portland, OR 97201-4197.
PY - 1997
Y1 - 1997
N2 - Purpose: Minocycline is a commonly used drug in the management of acne and rosacea. Four individual cases of oral minocycline-induced scleral pigmentation are reported in the dermatologic literature. This is the first report in the ophthalmic literature end will add three new cases of probable minocycline-induced scleral pigmentation. Materials and Methods: Data on minocycline from the spontaneous reporting systems of the National Registry of Drug-Induced Ocular Side Effects, Food and Drug Administration, World Health Organization, and Lederle Laboratories were reviewed as to minocycline-related scleral pigmentation. Photographs, published cases, discussions with the examining ophthalmologists, and the personal observation of one patient (case 1) are the basis of the authors' conclusions. Results: Seven cases of probable oral minocycline-induced scleral pigmentation are presented. These changes may or may not be associated with minocycline- induced pigmentary changes in other tissues, such as the skin, teeth, fingernails, bone, thyroid, or mucosa. The characteristic scleral pattern is a blue-gray 3- to 5-mm band starting at the limbus, which usually is enhanced in the palpebral aperture, possibly due to the photosensitizing properties of the drug. Conclusions: Oral minocycline can cause scleral pigmentation. This pigmentation may resolve within years, or it may be permanent.
AB - Purpose: Minocycline is a commonly used drug in the management of acne and rosacea. Four individual cases of oral minocycline-induced scleral pigmentation are reported in the dermatologic literature. This is the first report in the ophthalmic literature end will add three new cases of probable minocycline-induced scleral pigmentation. Materials and Methods: Data on minocycline from the spontaneous reporting systems of the National Registry of Drug-Induced Ocular Side Effects, Food and Drug Administration, World Health Organization, and Lederle Laboratories were reviewed as to minocycline-related scleral pigmentation. Photographs, published cases, discussions with the examining ophthalmologists, and the personal observation of one patient (case 1) are the basis of the authors' conclusions. Results: Seven cases of probable oral minocycline-induced scleral pigmentation are presented. These changes may or may not be associated with minocycline- induced pigmentary changes in other tissues, such as the skin, teeth, fingernails, bone, thyroid, or mucosa. The characteristic scleral pattern is a blue-gray 3- to 5-mm band starting at the limbus, which usually is enhanced in the palpebral aperture, possibly due to the photosensitizing properties of the drug. Conclusions: Oral minocycline can cause scleral pigmentation. This pigmentation may resolve within years, or it may be permanent.
UR - http://www.scopus.com/inward/record.url?scp=0030989965&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030989965&partnerID=8YFLogxK
U2 - 10.1016/S0161-6420(97)30204-8
DO - 10.1016/S0161-6420(97)30204-8
M3 - Article
C2 - 9186432
AN - SCOPUS:0030989965
SN - 0161-6420
VL - 104
SP - 936
EP - 938
JO - Ophthalmology
JF - Ophthalmology
IS - 6
ER -