3-Iodothyronamine (T 1AM) is an endogenous compound with chemical features that are similar to thyroid hormone. T 1AM has a carbon skeleton identical to that of T 4 and contains a single carboniodine bond. Theoretically, T 1AM could be produced from T 4 by enzymatic decarboxylation and deiodination. Recent studies show that T 1AM and higher iodinated thyronamines are subject to similar metabolic processing as iodothyronines such as T 4, suggesting a biological linkage between iodothyronines and iodothyronamines. In addition, single doses of T 1AM administered to rodents induce a hypometabolic state that in certain ways resembles hibernation and is opposite to the effects of excess T 4. This review will discuss the latest developments on this recently discovered thyroid hormone derivative.
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