Minimum information about a microarray experiment (MIAME) - Toward standards for microarray data

Alvis Brazma, Pascal Hingamp, John Quackenbush, Gavin Sherlock, Paul Spellman, Chris Stoeckert, John Aach, Wilhelm Ansorge, Catherine A. Ball, Helen C. Causton, Terry Gaasterland, Patrick Glenisson, Frank C.P. Holstege, Irene F. Kim, Victor Markowitz, John C. Matese, Helen Parkinson, Alan Robinson, Ugis Sarkans, Steffen Schulze-KremerJason Stewart, Ronald Taylor, Jaak Vilo, Martin Vingron

Research output: Contribution to journalReview article

3093 Scopus citations

Abstract

Microarray analysis has become a widely used tool for the generation of gene expression data on a genomic scale. Although many significant results have been derived from microarray studies, one limitation has been the lack of standards for presenting and exchanging such data. Here we present a proposal, the Minimum Information About a Microarray Experiment (MIAME), that describes the minimum information required to ensure that microarray data can be easily interpreted and that results derived from its analysis can be independently verified. The ultimate goal of this work is to establish a standard for recording and reporting microarray-based gene expression data, which will in turn facilitate the establishment of databases and public repositories and enable the development of data analysis tools. With respect to MIAME, we concentrate on defining the content and structure of the necessary information rather than the technical format for capturing it.

Original languageEnglish (US)
Pages (from-to)365-371
Number of pages7
JournalNature genetics
Volume29
Issue number4
DOIs
StatePublished - Dec 2001

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'Minimum information about a microarray experiment (MIAME) - Toward standards for microarray data'. Together they form a unique fingerprint.

  • Cite this

    Brazma, A., Hingamp, P., Quackenbush, J., Sherlock, G., Spellman, P., Stoeckert, C., Aach, J., Ansorge, W., Ball, C. A., Causton, H. C., Gaasterland, T., Glenisson, P., Holstege, F. C. P., Kim, I. F., Markowitz, V., Matese, J. C., Parkinson, H., Robinson, A., Sarkans, U., ... Vingron, M. (2001). Minimum information about a microarray experiment (MIAME) - Toward standards for microarray data. Nature genetics, 29(4), 365-371. https://doi.org/10.1038/ng1201-365