Minimizing variance in pediatric surgical care through implementation of a perioperative colon bundle: A multi-institution retrospective cohort study

Aaron J. Cunningham, Pavithra Rao, Raga Siddharthan, Kenneth S. Azarow, Arjun Ashok, Mubeen A. Jafri, Sanjay Krishnaswami, Nicholas A. Hamilton, Marilyn W. Butler, Katrine M. Lofberg, Andrew Zigman, Elizabeth A. Fialkowski

Research output: Contribution to journalArticle


Background: Employing an institutional initiative to minimize variance in pediatric surgical care, we implemented a set of perioperative bundled interventions for all colorectal procedures to reduce surgical site infections (SSIs). Methods: Implementation of a standard colon bundle at two children's hospitals began in December 2014. Subjects who underwent a colorectal procedure during the study period were analyzed. Demographics, outcomes, and complications were compared with Wilcoxon Rank-Sum, Chi-square and Fisher exact tests, as appropriate. Multivariable logistic regression was performed to assess the influence of time period (independent of protocol implementation) on the rate of subsequent infection. Results: One hundred and forty-five patients were identified (preprotocol = 68, postprotocol = 77). Gender, diagnosis, procedure performed and wound classification were similar between groups. Superficial SSIs (21% vs. 8%, p = 0.031) and readmission (16% vs. 4%, p = 0.021) were significantly decreased following implementation of a colon bundle. Median hospital days, cost, reoperation, intraabdominal abscess, and anastomotic leak were unchanged before and after protocol implementation (all p > 0.05). Multivariable logistic regression found time period to be independent of SSIs (OR: 0.810, 95% CI: 0.576–1.140). Conclusion: Implementation of a standard pediatric perioperative colon bundle can reduce superficial SSIs. Larger prospective studies are needed to evaluate the impact of colon bundles in reducing complications, hospital stay and cost. Level of evidence: III — Retrospective cohort study

Original languageEnglish (US)
JournalJournal of pediatric surgery
StateAccepted/In press - Jan 1 2020



  • Colon bundle
  • Pediatric surgery
  • Quality improvement
  • Surgical site infection

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

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