Minimal spinal hyperostosis with low-dose isotretinoin therapy

R. F. Kilcoyne, Ray Cope, William Cunningham, Francis A. Nardella, Susan Denman, Thomas J. Franz, Jon Hanifin

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Skeletal abnormalities have been reported on numerous occasions in patients who have received high doses of vitamin A and its derivatives. Recently, a new derivative, isotretinoin (Accutane, Hoffman-LaRoche, Inc.), has become available for the treatment of cystic acne. Ninety-six patients treated for a minimum of four months with low doses of this drug at two University centers have shown overall good to excellent clinical responses. However, ten of these patients have developed small pointed excrescences on the anterior margins of cervical, thoracic, or lumbar vertebral bodies. The findings are of unknown clinical significance but show some similarities to the spinal findings in DISH syndrome. Follow-up studies will be obtained, but, at the present time, the drug still can be recommended for patients who have severe cystic acne because of the excellent clinical response.

Original languageEnglish (US)
Pages (from-to)41-44
Number of pages4
JournalInvestigative Radiology
Volume21
Issue number1
StatePublished - 1986

Fingerprint

Hyperostosis
Isotretinoin
Acne Vulgaris
Therapeutics
Vitamin A
Pharmaceutical Preparations
Thorax

Keywords

  • Acne
  • DISH
  • Hyperostosis
  • Retinoids
  • Spine

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Kilcoyne, R. F., Cope, R., Cunningham, W., Nardella, F. A., Denman, S., Franz, T. J., & Hanifin, J. (1986). Minimal spinal hyperostosis with low-dose isotretinoin therapy. Investigative Radiology, 21(1), 41-44.

Minimal spinal hyperostosis with low-dose isotretinoin therapy. / Kilcoyne, R. F.; Cope, Ray; Cunningham, William; Nardella, Francis A.; Denman, Susan; Franz, Thomas J.; Hanifin, Jon.

In: Investigative Radiology, Vol. 21, No. 1, 1986, p. 41-44.

Research output: Contribution to journalArticle

Kilcoyne, RF, Cope, R, Cunningham, W, Nardella, FA, Denman, S, Franz, TJ & Hanifin, J 1986, 'Minimal spinal hyperostosis with low-dose isotretinoin therapy', Investigative Radiology, vol. 21, no. 1, pp. 41-44.
Kilcoyne RF, Cope R, Cunningham W, Nardella FA, Denman S, Franz TJ et al. Minimal spinal hyperostosis with low-dose isotretinoin therapy. Investigative Radiology. 1986;21(1):41-44.
Kilcoyne, R. F. ; Cope, Ray ; Cunningham, William ; Nardella, Francis A. ; Denman, Susan ; Franz, Thomas J. ; Hanifin, Jon. / Minimal spinal hyperostosis with low-dose isotretinoin therapy. In: Investigative Radiology. 1986 ; Vol. 21, No. 1. pp. 41-44.
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