TY - JOUR
T1 - Minimal spinal hyperostosis with low-dose isotretinoin therapy
AU - Kilcoyne, R. F.
AU - Cope, Ray
AU - Cunningham, William
AU - Nardella, Francis A.
AU - Denman, Susan
AU - Franz, Thomas J.
AU - Hanifin, Jon
PY - 1986/1
Y1 - 1986/1
N2 - Skeletal abnormalities have been reported on numerous occasions in patients who have received high doses of vitamin A and its derivatives. Recently, a new derivative, isotretinoin (Accutane, Hoffman-LaRoche, Inc.), has become available for the treatment of cystic acne. Ninety-six patients treated for a minimum of four months with low doses of this drug at two University centers have shown overall good to excellent clinical responses. However, ten of these patients have developed small pointed excrescences on the anterior margins of cervical, thoracic, or lumbar vertebral bodies. The findings are of unknown clinical significance but show some similarities to the spinal findings in DISH syndrome. Follow-up studies will be obtained, but, at the present time, the drug still can be recommended for patients who have severe cystic acne because of the excellent clinical response.
AB - Skeletal abnormalities have been reported on numerous occasions in patients who have received high doses of vitamin A and its derivatives. Recently, a new derivative, isotretinoin (Accutane, Hoffman-LaRoche, Inc.), has become available for the treatment of cystic acne. Ninety-six patients treated for a minimum of four months with low doses of this drug at two University centers have shown overall good to excellent clinical responses. However, ten of these patients have developed small pointed excrescences on the anterior margins of cervical, thoracic, or lumbar vertebral bodies. The findings are of unknown clinical significance but show some similarities to the spinal findings in DISH syndrome. Follow-up studies will be obtained, but, at the present time, the drug still can be recommended for patients who have severe cystic acne because of the excellent clinical response.
KW - Acne
KW - DISH
KW - Hyperostosis
KW - Retinoids
KW - Spine
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U2 - 10.1097/00004424-198601000-00007
DO - 10.1097/00004424-198601000-00007
M3 - Article
C2 - 2935510
AN - SCOPUS:0022630445
SN - 0020-9996
VL - 21
SP - 41
EP - 44
JO - Investigative Radiology
JF - Investigative Radiology
IS - 1
ER -