Abstract
HLA is a critical component of the viral antigen presentation pathway. We investigated the relationship between the severity of SARS-CoV-2 disease and HLA type in 3235 individuals with confirmed SARS-CoV-2 infection. We found only the DPB1 locus to be associated with the binary outcome of whether an individual developed any COVID-19 symptoms. The number of peptides predicted to bind to an HLA allele had no significant relationship with disease severity both when stratifying individuals by ancestry or age and in a pooled analysis. Overall, at the population level, we found HLA type is significantly less predictive of COVID-19 disease severity than certain demographic factors and clinical comorbidities.
Original language | English (US) |
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Pages (from-to) | 607-613 |
Number of pages | 7 |
Journal | HLA |
Volume | 99 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2022 |
Keywords
- COVID-19
- HLA
- SARS-CoV-2
- antigen presentation
- disease severity
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Genetics