Minimal observed impact of HLA genotype on hospitalization and severity of SARS-CoV-2 infection

Austin Nguyen, Tasneem Yusufali, Jill A. Hollenbach, Abhinav Nellore, Reid F. Thompson

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

HLA is a critical component of the viral antigen presentation pathway. We investigated the relationship between the severity of SARS-CoV-2 disease and HLA type in 3235 individuals with confirmed SARS-CoV-2 infection. We found only the DPB1 locus to be associated with the binary outcome of whether an individual developed any COVID-19 symptoms. The number of peptides predicted to bind to an HLA allele had no significant relationship with disease severity both when stratifying individuals by ancestry or age and in a pooled analysis. Overall, at the population level, we found HLA type is significantly less predictive of COVID-19 disease severity than certain demographic factors and clinical comorbidities.

Original languageEnglish (US)
Pages (from-to)607-613
Number of pages7
JournalHLA
Volume99
Issue number6
DOIs
StatePublished - Jun 2022

Keywords

  • COVID-19
  • HLA
  • SARS-CoV-2
  • antigen presentation
  • disease severity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Genetics

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