Minimal change disease in pregnancy

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: New onset minimal change disease (MCD) is rare in pregnancy with the potential for serious complications including acute kidney injury (AKI). Case: A case of MCD was diagnosed at 19 weeks gestation by renal biopsy. Within one month of starting steroids, the patient experienced normalization of renal function and resolution of nephrotic syndrome, although hemodialysis was needed as a temporizing measure. Conclusion: The differential diagnosis for new onset proteinuria in pregnancy should include MCD. In selected cases, renal biopsy can be used to confirm diagnosis, and when indicated, hemodialysis should be instituted while awaiting a response to steroid therapy.

Original languageEnglish (US)
Pages (from-to)1282-1284
Number of pages3
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume27
Issue number12
DOIs
StatePublished - 2014

Fingerprint

Lipoid Nephrosis
Kidney
Pregnancy
Renal Dialysis
Steroids
Biopsy
Nephrotic Syndrome
Proteinuria
Acute Kidney Injury
Differential Diagnosis
Therapeutics

Keywords

  • Acute kidney injury
  • Minimal change disease
  • Nephrotic syndrome
  • Pregnancy complications
  • Renal disease

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology
  • Medicine(all)

Cite this

Minimal change disease in pregnancy. / Lo, Jamie; Kerns, Eric; Rueda, Jose; Marshall, Nicole.

In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 27, No. 12, 2014, p. 1282-1284.

Research output: Contribution to journalArticle

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AB - Background: New onset minimal change disease (MCD) is rare in pregnancy with the potential for serious complications including acute kidney injury (AKI). Case: A case of MCD was diagnosed at 19 weeks gestation by renal biopsy. Within one month of starting steroids, the patient experienced normalization of renal function and resolution of nephrotic syndrome, although hemodialysis was needed as a temporizing measure. Conclusion: The differential diagnosis for new onset proteinuria in pregnancy should include MCD. In selected cases, renal biopsy can be used to confirm diagnosis, and when indicated, hemodialysis should be instituted while awaiting a response to steroid therapy.

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