Mindapyrroles A-C, Pyoluteorin Analogues from a Shipworm-Associated Bacterium

Noel M. Lacerna, Bailey W. Miller, Albebson L. Lim, Jortan O. Tun, Jose Miguel D. Robes, Mark Jeremiah B. Cleofas, Zhenjian Lin, Lilibeth A. Salvador-Reyes, Margo G. Haygood, Eric W. Schmidt, Gisela P. Concepcion

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Three new pyoluteorin analogues, mindapyrroles A-C (1-3), were purified from Pseudomonas aeruginosa strain 1682U.R.0a.27, a gill-associated bacterium isolated from the tissue homogenate of the giant shipworm Kuphus polythalamius. Mindapyrroles B and C inhibit the growth of multiple pathogenic bacteria, with mindapyrrole B (2) showing the most potent antimicrobial activity and widest selectivity index over mammalian cells. Preliminary structure-activity relationship analysis showed that dimerization of the pyoluteorin moiety through a C-C linkage is detrimental to the antimicrobial activity, but addition of an aerugine unit in the methylene bridge is favorable for both the antimicrobial activity and selectivity index.

Original languageEnglish (US)
Pages (from-to)1024-1028
Number of pages5
JournalJournal of Natural Products
Issue number4
StatePublished - Apr 26 2019

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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