Mild pressure loading alters right ventricular function in fetal sheep

C. W. Pinson, M. J. Morton, Kent Thornburg

    Research output: Contribution to journalArticle

    29 Citations (Scopus)

    Abstract

    Right ventricular function before and during 10 days of mild pressure loading (10 mm Hg increase in mean pulmonary arterial pressure) was compared with right ventricular function in unloaded near-term fetal sheep. Pressure loading did not alter fetal arterial blood gases or vascular pressures. The right ventricular function curve (stroke volume versus mean right atrial pressure) was not significantly altered by loading. However, the relation between right ventricular stroke volume and increased arterial pressure was dramatically shifted upward, indicating improved ventricular function after the 10-day loading period. Normalized free wall of the loaded right ventricles became thicker (1.2 ± 0.2 versus 0.9 ± 0.2 mm/kg, p <0.01) and heavier (2.7 ± 0.4 g/kg versus 2.2 ± 0.4 g/kg, p <0.05) than control, and the ratio of the equatorial radius of curvature to wall thickness decreased (3.2 ± 0.5 versus 4.5 ± 0.9, p <0.005). Left ventricular free wall and septal weights and thicknesses were not significantly changed. The in vitro diastolic pressure-volume curves of both ventricular chambers of loaded hearts shifted to the left, indicating smaller ventricles than controls at physiological filling pressures. These data suggest the transduction of right ventricular loading effects to the left ventricle. Improved right ventricular function after loading is predicted by the law of Laplace based on the decreased radius of curvature-to-wall thickness ratio.

    Original languageEnglish (US)
    Pages (from-to)947-957
    Number of pages11
    JournalCirculation Research
    Volume68
    Issue number4
    StatePublished - 1991

    Fingerprint

    Right Ventricular Function
    Sheep
    Pressure
    Stroke Volume
    Heart Ventricles
    Arterial Pressure
    Atrial Pressure
    Ventricular Function
    Fetal Blood
    Blood Vessels
    Gases
    Blood Pressure
    Weights and Measures
    Lung

    Keywords

    • fetus
    • heart
    • hypertrophy
    • pressure-volume curve
    • ventricle

    ASJC Scopus subject areas

    • Physiology
    • Cardiology and Cardiovascular Medicine

    Cite this

    Mild pressure loading alters right ventricular function in fetal sheep. / Pinson, C. W.; Morton, M. J.; Thornburg, Kent.

    In: Circulation Research, Vol. 68, No. 4, 1991, p. 947-957.

    Research output: Contribution to journalArticle

    Pinson, C. W. ; Morton, M. J. ; Thornburg, Kent. / Mild pressure loading alters right ventricular function in fetal sheep. In: Circulation Research. 1991 ; Vol. 68, No. 4. pp. 947-957.
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