Mifepristone regulates expression of apoptosis related genes Fas and FasL in mouse endometrium

F. Gao, Fuhua Xu, X. C. Zhou, X. B. Han, Y. X. Liu

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

AIM: To investigate the anti-implantation mechanism of mifepriston. METHODS: In situ hybridization and immunohistochemistry were applied to determine mRNA and protein. RESULTS: After mifepriston injection, the number of implantation sites were obviously reduced, mifepriston could inhibit the embryo implantation in mouse. The expression of apoptosis related genes, Fas and FasL, in mouse endometrium was also decreased after mifepriston treatment. CONCLUSION: The expression of apoptosis related genes Fas and FasL is regulated by mifepriston and the inhibitory effect of mifepriston on the embryo implantation may be mediated by action on the Fas/FasL system.

Original languageEnglish (US)
Pages (from-to)524-529
Number of pages6
JournalActa Pharmacologica Sinica
Volume22
Issue number6
StatePublished - 2001
Externally publishedYes

Fingerprint

Mifepristone
Endometrium
Genes
Apoptosis
In Situ Hybridization
Immunohistochemistry
Messenger RNA
Injections
Proteins
Therapeutics

Keywords

  • Apoptosis
  • Immunohistochemistry
  • In situ hybridization
  • Mifepristone

ASJC Scopus subject areas

  • Chemistry(all)
  • Pharmacology

Cite this

Gao, F., Xu, F., Zhou, X. C., Han, X. B., & Liu, Y. X. (2001). Mifepristone regulates expression of apoptosis related genes Fas and FasL in mouse endometrium. Acta Pharmacologica Sinica, 22(6), 524-529.

Mifepristone regulates expression of apoptosis related genes Fas and FasL in mouse endometrium. / Gao, F.; Xu, Fuhua; Zhou, X. C.; Han, X. B.; Liu, Y. X.

In: Acta Pharmacologica Sinica, Vol. 22, No. 6, 2001, p. 524-529.

Research output: Contribution to journalArticle

Gao, F, Xu, F, Zhou, XC, Han, XB & Liu, YX 2001, 'Mifepristone regulates expression of apoptosis related genes Fas and FasL in mouse endometrium', Acta Pharmacologica Sinica, vol. 22, no. 6, pp. 524-529.
Gao, F. ; Xu, Fuhua ; Zhou, X. C. ; Han, X. B. ; Liu, Y. X. / Mifepristone regulates expression of apoptosis related genes Fas and FasL in mouse endometrium. In: Acta Pharmacologica Sinica. 2001 ; Vol. 22, No. 6. pp. 524-529.
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