Mifepristone regulates expression of apoptosis related genes Fas and FasL in mouse endometrium

F. Gao, F. H. Xu, X. C. Zhou, X. B. Han, Y. X. Liu

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    Abstract

    AIM: To investigate the anti-implantation mechanism of mifepriston. METHODS: In situ hybridization and immunohistochemistry were applied to determine mRNA and protein. RESULTS: After mifepriston injection, the number of implantation sites were obviously reduced, mifepriston could inhibit the embryo implantation in mouse. The expression of apoptosis related genes, Fas and FasL, in mouse endometrium was also decreased after mifepriston treatment. CONCLUSION: The expression of apoptosis related genes Fas and FasL is regulated by mifepriston and the inhibitory effect of mifepriston on the embryo implantation may be mediated by action on the Fas/FasL system.

    Original languageEnglish (US)
    Pages (from-to)524-529
    Number of pages6
    JournalActa Pharmacologica Sinica
    Volume22
    Issue number6
    StatePublished - Jul 3 2001

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    Keywords

    • Apoptosis
    • Immunohistochemistry
    • In situ hybridization
    • Mifepristone

    ASJC Scopus subject areas

    • Pharmacology
    • Pharmacology (medical)

    Cite this

    Gao, F., Xu, F. H., Zhou, X. C., Han, X. B., & Liu, Y. X. (2001). Mifepristone regulates expression of apoptosis related genes Fas and FasL in mouse endometrium. Acta Pharmacologica Sinica, 22(6), 524-529.