Microwave assisted Westphal condensation and its application to synthesis of sempervirine and related compounds

T. S. Chinta Rao, Sanjay Saha, Gajendra B. Raolji, Balaram Patro, Prabhaker Risbood, Michael J. Difilippantonio, Joseph E. Tomaszewski, Sanjay V. Malhotra

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

A concise synthesis of a potent lead in anticancer therapeutics, sempervirine, was achieved by one pot Westphal condensation, ester hydrolysis, and decarboxylation under microwave irradiation. The method was extended to the synthesis of several similar heterocycles.

Original languageEnglish (US)
Pages (from-to)487-490
Number of pages4
JournalTetrahedron Letters
Volume54
Issue number6
DOIs
StatePublished - Feb 6 2013
Externally publishedYes

Keywords

  • Antiproliferative agent
  • DNA intercalator
  • Microwave assisted
  • Sempervirine
  • Westphal condensation

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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