Microvessel density and p53 mutations in advanced-stage epithelial ovarian cancer

Niyati J. Nadkarni, Koen De Geest, Traci Neff, Barry De Young, David P. Bender, Amina Ahmed, Brian J. Smith, Anna Button, Michael J. Goodheart

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

We planned to determine the relationship between angiogenesis and p53 mutational status in advanced-stage epithelial ovarian cancer. Using 190 tumor samples from patients with stage III and IV ovarian cancer we performed p53 sequencing, immunohistochemistry, and CD31 microvessel density (MVD) determination. MVD was elevated in tumors with p53 null mutations compared to p53 missense mutation or no mutation. Disease recurrence was increased with higher MVD in both unadjusted and adjusted analyses. In adjusted analysis, p53 null mutation was associated with increased recurrence and worse overall survival. Worse overall survival and increased recurrence risk were also associated with the combination of CD31 MVD values >25 vessels/HPF and any p53 mutation. P53 mutation status and MVD may have prognostic significance in patients with advanced-stage ovarian cancer. Tumors with p53 null mutations are likely to be more vascular, contributing to decreased survival and increased recurrence probability.

Original languageEnglish (US)
Pages (from-to)99-104
Number of pages6
JournalCancer Letters
Volume331
Issue number1
DOIs
StatePublished - Apr 30 2013

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Keywords

  • Angiogenesis
  • Microvessel density
  • Ovarian cancer
  • P53 mutation
  • Survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Nadkarni, N. J., Geest, K. D., Neff, T., Young, B. D., Bender, D. P., Ahmed, A., Smith, B. J., Button, A., & Goodheart, M. J. (2013). Microvessel density and p53 mutations in advanced-stage epithelial ovarian cancer. Cancer Letters, 331(1), 99-104. https://doi.org/10.1016/j.canlet.2012.12.016