TY - JOUR
T1 - Microvasculature in Acute Myocardial Ischemia
T2 - Part II. Evolving Concepts in Pathophysiology, Diagnosis, and Treatment
AU - Kaul, Sanjiv
AU - Ito, Hiroshi
PY - 2004/1/27
Y1 - 2004/1/27
N2 - MCE has provided valuable information regarding the microcirculation in animal models as well as in humans. In this brief update, we have tried to summarize the state of the microcirculation during stress-induced ischemia, AMI, and inflammation caused by reperfusion. We have also highlighted the importance of capillary resistance and blood viscosity, as well as collateral blood flow, in maintaining myocardial viability. We have discussed treatment options aimed at increasing flow to regions with microvascular obstruction to improve outcome. Future progress in AMI therapy will be geared toward protecting the myocardium during ischemic and reperfusion injury through improvement in microvascular flow and function. In order to achieve this goal, a comprehensive understanding of the normal and abnormal workings of the coronary microcirculation is essential. We hope this Clinical Update contributes in small measure toward that understanding.
AB - MCE has provided valuable information regarding the microcirculation in animal models as well as in humans. In this brief update, we have tried to summarize the state of the microcirculation during stress-induced ischemia, AMI, and inflammation caused by reperfusion. We have also highlighted the importance of capillary resistance and blood viscosity, as well as collateral blood flow, in maintaining myocardial viability. We have discussed treatment options aimed at increasing flow to regions with microvascular obstruction to improve outcome. Future progress in AMI therapy will be geared toward protecting the myocardium during ischemic and reperfusion injury through improvement in microvascular flow and function. In order to achieve this goal, a comprehensive understanding of the normal and abnormal workings of the coronary microcirculation is essential. We hope this Clinical Update contributes in small measure toward that understanding.
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U2 - 10.1161/01.CIR.0000111583.89777.F9
DO - 10.1161/01.CIR.0000111583.89777.F9
M3 - Review article
C2 - 14744956
AN - SCOPUS:1642580536
SN - 0009-7322
VL - 109
SP - 310
EP - 315
JO - Circulation
JF - Circulation
IS - 3
ER -