Microscopically positive margins for primary gastrointestinal stromal tumors: Analysis of risk factors and tumor recurrence

Martin D. McCarter, Cristina R. Antonescu, Karla V. Ballman, Robert G. Maki, Peter W T Pisters, George D. Demetri, Charles Blanke, Margaret Von Mehren, Murray F. Brennan, Linda McCall, David M. Ota, Ronald P. DeMatteo

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80 Scopus citations

Abstract

BACKGROUND: Little is known about the outcomes of patients with microscopically positive (R1) resections for primary gastrointestinal stromal tumors (GIST) because existing retrospective series contain small numbers of patients. The objective of this study was to analyze factors associated with R1 resection and assess the risk of recurrence with and without imatinib. STUDY DESIGN: We reviewed operative and pathology reports for 819 patients undergoing resection of primary GIST from the North American branch of the American College of Surgeons Oncology Group (ACOSOG) Z9000 and Z9001 clinical trials at 230 institutions testing adjuvant imatinib after resection of primary GIST. Patient, tumor, operative characteristics, factors associated with R1 resections, and disease status were analyzed. RESULTS: Seventy-two (8.8%) patients had an R1 resection and were followed for a median of 49 months. Factors associated with R1 resection included tumor size (

Original languageEnglish (US)
Pages (from-to)53-59
Number of pages7
JournalJournal of the American College of Surgeons
Volume215
Issue number1
DOIs
Publication statusPublished - Jul 2012
Externally publishedYes

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ASJC Scopus subject areas

  • Surgery

Cite this

McCarter, M. D., Antonescu, C. R., Ballman, K. V., Maki, R. G., Pisters, P. W. T., Demetri, G. D., ... DeMatteo, R. P. (2012). Microscopically positive margins for primary gastrointestinal stromal tumors: Analysis of risk factors and tumor recurrence. Journal of the American College of Surgeons, 215(1), 53-59. https://doi.org/10.1016/j.jamcollsurg.2012.05.008