Microscale hydrogels for medicine and biology

Synthesis characteristics and applications

Christopher Rivest, David W.G. Morrison, Bin Ni, Jamie Rubin, Vikramaditya Yadav, Alborz Mahdavi, Jeffrey M. Karp, Ali Khademhosseini

Research output: Contribution to journalReview article

52 Citations (Scopus)

Abstract

Microscale hydrogels with dimensions of 200 μm or less are powerful tools for various biomedical applications such as tissue engineering, drug delivery, and biosensors, due to their size, biocompatibility, and their controllable biological, chemical, and mechanical properties. In this review, we provide a broad overview of the approaches used to synthesize and characterize microgels, as well as their applications. We discuss the various methods used to fabricate microgels, such as emulsification, micromolding, microfluidics, and photolithography. Furthermore, we discuss the effects of porosity and crosslinking density on the mechanical and biological properties of hydrogels. In addition, we give specific examples of the use of hydrogels, such as scaffolds and cell encapsulation for tissue engineering, controlled release materials for drug delivery, and environmentally sensitive sensors for microdevices. Finally, we will discuss the future applications of this technology.

Original languageEnglish (US)
Pages (from-to)1103-1119
Number of pages17
JournalJournal of Mechanics of Materials and Structures
Volume2
Issue number6
DOIs
StatePublished - Jan 1 2007
Externally publishedYes

Fingerprint

Hydrogel
Hydrogels
Medicine
Biology
Tissue Engineering
Drug Delivery
Synthesis
Drug delivery
Tissue engineering
Photolithography
Biomedical Applications
Emulsification
Biosensor
Encapsulation
Scaffold
Microfluidics
Scaffolds (biology)
Porosity
Biocompatibility
Biosensors

Keywords

  • Biomaterials
  • BioMEMS
  • Biosensor
  • Drug delivery
  • Hydrophilic polymer
  • Regenerative medicine
  • Stem cells
  • Tissue engineering

ASJC Scopus subject areas

  • Mechanics of Materials
  • Applied Mathematics

Cite this

Microscale hydrogels for medicine and biology : Synthesis characteristics and applications. / Rivest, Christopher; Morrison, David W.G.; Ni, Bin; Rubin, Jamie; Yadav, Vikramaditya; Mahdavi, Alborz; Karp, Jeffrey M.; Khademhosseini, Ali.

In: Journal of Mechanics of Materials and Structures, Vol. 2, No. 6, 01.01.2007, p. 1103-1119.

Research output: Contribution to journalReview article

Rivest, C, Morrison, DWG, Ni, B, Rubin, J, Yadav, V, Mahdavi, A, Karp, JM & Khademhosseini, A 2007, 'Microscale hydrogels for medicine and biology: Synthesis characteristics and applications', Journal of Mechanics of Materials and Structures, vol. 2, no. 6, pp. 1103-1119. https://doi.org/10.2140/jomms.2007.2.1103
Rivest, Christopher ; Morrison, David W.G. ; Ni, Bin ; Rubin, Jamie ; Yadav, Vikramaditya ; Mahdavi, Alborz ; Karp, Jeffrey M. ; Khademhosseini, Ali. / Microscale hydrogels for medicine and biology : Synthesis characteristics and applications. In: Journal of Mechanics of Materials and Structures. 2007 ; Vol. 2, No. 6. pp. 1103-1119.
@article{c8e8f4cb1dac4421a7711f35ece67da5,
title = "Microscale hydrogels for medicine and biology: Synthesis characteristics and applications",
abstract = "Microscale hydrogels with dimensions of 200 μm or less are powerful tools for various biomedical applications such as tissue engineering, drug delivery, and biosensors, due to their size, biocompatibility, and their controllable biological, chemical, and mechanical properties. In this review, we provide a broad overview of the approaches used to synthesize and characterize microgels, as well as their applications. We discuss the various methods used to fabricate microgels, such as emulsification, micromolding, microfluidics, and photolithography. Furthermore, we discuss the effects of porosity and crosslinking density on the mechanical and biological properties of hydrogels. In addition, we give specific examples of the use of hydrogels, such as scaffolds and cell encapsulation for tissue engineering, controlled release materials for drug delivery, and environmentally sensitive sensors for microdevices. Finally, we will discuss the future applications of this technology.",
keywords = "Biomaterials, BioMEMS, Biosensor, Drug delivery, Hydrophilic polymer, Regenerative medicine, Stem cells, Tissue engineering",
author = "Christopher Rivest and Morrison, {David W.G.} and Bin Ni and Jamie Rubin and Vikramaditya Yadav and Alborz Mahdavi and Karp, {Jeffrey M.} and Ali Khademhosseini",
year = "2007",
month = "1",
day = "1",
doi = "10.2140/jomms.2007.2.1103",
language = "English (US)",
volume = "2",
pages = "1103--1119",
journal = "Journal of Mechanics of Materials and Structures",
issn = "1559-3959",
publisher = "Mathematical Sciences Publishers",
number = "6",

}

TY - JOUR

T1 - Microscale hydrogels for medicine and biology

T2 - Synthesis characteristics and applications

AU - Rivest, Christopher

AU - Morrison, David W.G.

AU - Ni, Bin

AU - Rubin, Jamie

AU - Yadav, Vikramaditya

AU - Mahdavi, Alborz

AU - Karp, Jeffrey M.

AU - Khademhosseini, Ali

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Microscale hydrogels with dimensions of 200 μm or less are powerful tools for various biomedical applications such as tissue engineering, drug delivery, and biosensors, due to their size, biocompatibility, and their controllable biological, chemical, and mechanical properties. In this review, we provide a broad overview of the approaches used to synthesize and characterize microgels, as well as their applications. We discuss the various methods used to fabricate microgels, such as emulsification, micromolding, microfluidics, and photolithography. Furthermore, we discuss the effects of porosity and crosslinking density on the mechanical and biological properties of hydrogels. In addition, we give specific examples of the use of hydrogels, such as scaffolds and cell encapsulation for tissue engineering, controlled release materials for drug delivery, and environmentally sensitive sensors for microdevices. Finally, we will discuss the future applications of this technology.

AB - Microscale hydrogels with dimensions of 200 μm or less are powerful tools for various biomedical applications such as tissue engineering, drug delivery, and biosensors, due to their size, biocompatibility, and their controllable biological, chemical, and mechanical properties. In this review, we provide a broad overview of the approaches used to synthesize and characterize microgels, as well as their applications. We discuss the various methods used to fabricate microgels, such as emulsification, micromolding, microfluidics, and photolithography. Furthermore, we discuss the effects of porosity and crosslinking density on the mechanical and biological properties of hydrogels. In addition, we give specific examples of the use of hydrogels, such as scaffolds and cell encapsulation for tissue engineering, controlled release materials for drug delivery, and environmentally sensitive sensors for microdevices. Finally, we will discuss the future applications of this technology.

KW - Biomaterials

KW - BioMEMS

KW - Biosensor

KW - Drug delivery

KW - Hydrophilic polymer

KW - Regenerative medicine

KW - Stem cells

KW - Tissue engineering

UR - http://www.scopus.com/inward/record.url?scp=34548796454&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548796454&partnerID=8YFLogxK

U2 - 10.2140/jomms.2007.2.1103

DO - 10.2140/jomms.2007.2.1103

M3 - Review article

VL - 2

SP - 1103

EP - 1119

JO - Journal of Mechanics of Materials and Structures

JF - Journal of Mechanics of Materials and Structures

SN - 1559-3959

IS - 6

ER -