MicroRNAs in Cancer: Challenges and Opportunities in Early Detection, Disease Monitoring, and Therapeutic Agents

Namita Chatterjee, Shushan Rana, Cristina Espinosa-Diez, Sudarshan Anand

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Purpose of Review: The goals of this review are to examine the usefulness of microRNAs (miRNAs) as diagnostic and prognostic biomarkers for cancer and to evaluate the applicability of miRNAs as cancer therapeutics. Recent Findings: Examination of miRNA milieu from body fluids offers a new alternative for quick, affordable, and easy analysis of disease status in patients. Blood-based exosomal miRNAs have increased stability and are an excellent choice for clinical cancer diagnostics and prognostics. Currently, there are many miRNA signatures associated with cancer and progression but there is no consensus among multiple serum and tumor sample studies. Off-target and immunological effects remain an obstacle for the use of miRNAs as novel chemotherapeutics in the clinic. Recent developments in nanotechnology and drug delivery systems which target the tumor microenvironment may provide an alternative therapeutic approach with decreased toxicity. Summary: This review critically evaluates the literature investigating the use of miRNAs as biomarkers and their future as potential therapeutics.

Original languageEnglish (US)
Pages (from-to)35-42
Number of pages8
JournalCurrent Pathobiology Reports
Volume5
Issue number1
DOIs
StatePublished - Mar 1 2017

Keywords

  • Biomarker
  • Cancer
  • Chemotherapy
  • Exosomes
  • MicroRNA
  • Tumor microenvironment

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Pathology and Forensic Medicine
  • Cancer Research

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