TY - JOUR
T1 - MicroRNA regulation of neural stem cells and neurogenesis
AU - Shi, Yanhong
AU - Zhao, Xinyu
AU - Hsieh, Jenny
AU - Wichterle, Hynek
AU - Impey, Soren
AU - Banerjee, Sourav
AU - Neveu, Pierre
AU - Kosik, Kenneth S.
PY - 2010/11/10
Y1 - 2010/11/10
N2 - MicroRNAs are a class of small RNA regulators that are involved in numerous cellular processes, including development, proliferation, differentiation, and plasticity. The emerging concept is that microRNAs play a central role in controlling the balance between stem cell self-renewal and fate determination by regulating the expression of stem cell regulators. This review will highlight recent advances in the regulation of neural stem cell self-renewal and neurogenesis by microRNAs. It will cover microRNA functions during the entire process of neurogenesis, from neural stem cell self-renewal and fate determination to neuronal maturation, synaptic formation, and plasticity. The interplay between microRNAs and both cell-intrinsic and -extrinsic stem cell players, including transcription factors, epigenetic regulators, and extrinsic signaling molecules will be discussed. This is a summary of the topics covered in the mini-symposium on microRNA regulation of neural stem cells and neurogenesis in SFN 2010 and is not meant to be a comprehensive review of the subject.
AB - MicroRNAs are a class of small RNA regulators that are involved in numerous cellular processes, including development, proliferation, differentiation, and plasticity. The emerging concept is that microRNAs play a central role in controlling the balance between stem cell self-renewal and fate determination by regulating the expression of stem cell regulators. This review will highlight recent advances in the regulation of neural stem cell self-renewal and neurogenesis by microRNAs. It will cover microRNA functions during the entire process of neurogenesis, from neural stem cell self-renewal and fate determination to neuronal maturation, synaptic formation, and plasticity. The interplay between microRNAs and both cell-intrinsic and -extrinsic stem cell players, including transcription factors, epigenetic regulators, and extrinsic signaling molecules will be discussed. This is a summary of the topics covered in the mini-symposium on microRNA regulation of neural stem cells and neurogenesis in SFN 2010 and is not meant to be a comprehensive review of the subject.
UR - http://www.scopus.com/inward/record.url?scp=78149478782&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78149478782&partnerID=8YFLogxK
U2 - 10.1523/JNEUROSCI.4280-10.2010
DO - 10.1523/JNEUROSCI.4280-10.2010
M3 - Article
C2 - 21068294
AN - SCOPUS:78149478782
SN - 0270-6474
VL - 30
SP - 14931
EP - 14936
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 45
ER -