TY - JOUR
T1 - MicroRNA pathways in neural development and plasticity
AU - Vo, Ngan K.
AU - Cambronne, Xiaolu A.
AU - Goodman, Richard H.
N1 - Funding Information:
We would like to thank Gail Mandel and Stephen Magill for critical review of this manuscript. This work was supported by grants from the NIH.
PY - 2010/8
Y1 - 2010/8
N2 - MicroRNAs contribute significantly to the development, survival, function, and plasticity of neurons. They silence expression of target genes by reducing mRNA stability and translation. Production of microRNAs is controlled via developmental and environmental cues and these small molecules, in concert with classical transcriptional regulators, amplify changes in neuronal maturation, dendrite morphogenesis, and synaptogenesis. Neurons compartmentalize mRNAs and microRNAs within specific subcellular domains to facilitate control of local protein synthesis in response to neuronal stimuli and to modulate synaptic plasticity. This review addresses issues relevant to microRNA function in neurons, in particular, their ability to reinforce developmental decisions and promote synaptic plasticity.
AB - MicroRNAs contribute significantly to the development, survival, function, and plasticity of neurons. They silence expression of target genes by reducing mRNA stability and translation. Production of microRNAs is controlled via developmental and environmental cues and these small molecules, in concert with classical transcriptional regulators, amplify changes in neuronal maturation, dendrite morphogenesis, and synaptogenesis. Neurons compartmentalize mRNAs and microRNAs within specific subcellular domains to facilitate control of local protein synthesis in response to neuronal stimuli and to modulate synaptic plasticity. This review addresses issues relevant to microRNA function in neurons, in particular, their ability to reinforce developmental decisions and promote synaptic plasticity.
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U2 - 10.1016/j.conb.2010.04.002
DO - 10.1016/j.conb.2010.04.002
M3 - Review article
C2 - 20447821
AN - SCOPUS:77957198050
SN - 0959-4388
VL - 20
SP - 457
EP - 465
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 4
ER -