TY - GEN
T1 - Microreactor-based system for radiolabeling of biomolecules with metallic radioisotopes
AU - Desai, Amit V.
AU - Zeng, Dexing
AU - Wheeler, Tobias D.
AU - Ranganathan, David
AU - Reichert, David E.
AU - Kenis, Paul J.A.
PY - 2011
Y1 - 2011
N2 - Here, we report a robust, versatile, compact microreactor-based system for labeling of biomolecules with metallic radioisotopes or radiometals. The microreactor exploits rapid mixing in grooved (staggered herringbones) microchannels, and efficient heat transfer in micro-incubation chambers to achieve high radiolabeling efficiencies. We demonstrate the application of the system by labeling RGD, a cancer-targeting biomolecule, with radioisotopes of copper and gallium. More significantly, the high labeling efficiencies were achieved without using excess of any reagents, thus obviating the need for subsequent purification. The reported microreactor-based system has potential for the synthesis of radiopharmaceuticals for clinical and research applications.
AB - Here, we report a robust, versatile, compact microreactor-based system for labeling of biomolecules with metallic radioisotopes or radiometals. The microreactor exploits rapid mixing in grooved (staggered herringbones) microchannels, and efficient heat transfer in micro-incubation chambers to achieve high radiolabeling efficiencies. We demonstrate the application of the system by labeling RGD, a cancer-targeting biomolecule, with radioisotopes of copper and gallium. More significantly, the high labeling efficiencies were achieved without using excess of any reagents, thus obviating the need for subsequent purification. The reported microreactor-based system has potential for the synthesis of radiopharmaceuticals for clinical and research applications.
KW - Cancer imaging and therapy
KW - Radiometals
KW - Radiopharmaceutical synthesis
KW - Staggered herringbone mixers
UR - http://www.scopus.com/inward/record.url?scp=84883823285&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84883823285&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84883823285
SN - 9781618395955
T3 - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
SP - 1576
EP - 1578
BT - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
T2 - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Y2 - 2 October 2011 through 6 October 2011
ER -