Microreactor-based system for radiolabeling of biomolecules with metallic radioisotopes

Amit V. Desai, Dexing Zeng, Tobias D. Wheeler, David Ranganathan, David E. Reichert, Paul J.A. Kenis

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Here, we report a robust, versatile, compact microreactor-based system for labeling of biomolecules with metallic radioisotopes or radiometals. The microreactor exploits rapid mixing in grooved (staggered herringbones) microchannels, and efficient heat transfer in micro-incubation chambers to achieve high radiolabeling efficiencies. We demonstrate the application of the system by labeling RGD, a cancer-targeting biomolecule, with radioisotopes of copper and gallium. More significantly, the high labeling efficiencies were achieved without using excess of any reagents, thus obviating the need for subsequent purification. The reported microreactor-based system has potential for the synthesis of radiopharmaceuticals for clinical and research applications.

Original languageEnglish (US)
Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages1576-1578
Number of pages3
StatePublished - Dec 1 2011
Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
Duration: Oct 2 2011Oct 6 2011

Publication series

Name15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Volume3

Conference

Conference15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
CountryUnited States
CitySeattle, WA
Period10/2/1110/6/11

Keywords

  • Cancer imaging and therapy
  • Radiometals
  • Radiopharmaceutical synthesis
  • Staggered herringbone mixers

ASJC Scopus subject areas

  • Control and Systems Engineering

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  • Cite this

    Desai, A. V., Zeng, D., Wheeler, T. D., Ranganathan, D., Reichert, D. E., & Kenis, P. J. A. (2011). Microreactor-based system for radiolabeling of biomolecules with metallic radioisotopes. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 (pp. 1576-1578). (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011; Vol. 3).