Microinjection of morphine into nucleus reticularis paragigantocellularis of the rat: suppression of noxious-evoked activity of nucleus raphe magnus neurons

Mary M. Heinricher; J. Peter Rosenfeld

doi:10.1016/0006-8993(85)91458-1

Microinjection of morphine into nucleus reticularis paragigantocellularis of the rat: suppression of noxious-evoked activity of nucleus raphe magnus neurons

Mary M. Heinricher, J. Peter Rosenfeld

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Microinjection of 1 μg of morphine into nucleus reticularis paragigantocellularis (Pgc) of anesthetized rats depressed both noxious-evoked and spontaneous activity of nociresponsive neurons in the nucleus raphe magnus (NRM). This effect was naloxone-reversible, and was not observed after control injections dorsal to Pgc. The percent change in spontaneous firing was significantly greater than the percent change in pinch-evoked firing. This reduction in NRM neuronal discharge may contribute to the antinociceptive effects produced by microinjection of morphine into Pgc.

Original language	English (US)
Pages (from-to)	388-391
Number of pages	4
Journal	Brain research
Volume	359
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(85)91458-1
State	Published - Dec 16 1985
Externally published	Yes

Keywords

analgesia
microinjection
morphine
nucleus raphe magnus
nucleus reticularis paragigantocellularis
pain

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(85)91458-1

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title = "Microinjection of morphine into nucleus reticularis paragigantocellularis of the rat: suppression of noxious-evoked activity of nucleus raphe magnus neurons",

abstract = "Microinjection of 1 μg of morphine into nucleus reticularis paragigantocellularis (Pgc) of anesthetized rats depressed both noxious-evoked and spontaneous activity of nociresponsive neurons in the nucleus raphe magnus (NRM). This effect was naloxone-reversible, and was not observed after control injections dorsal to Pgc. The percent change in spontaneous firing was significantly greater than the percent change in pinch-evoked firing. This reduction in NRM neuronal discharge may contribute to the antinociceptive effects produced by microinjection of morphine into Pgc.",

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AU - Rosenfeld, J. Peter

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N2 - Microinjection of 1 μg of morphine into nucleus reticularis paragigantocellularis (Pgc) of anesthetized rats depressed both noxious-evoked and spontaneous activity of nociresponsive neurons in the nucleus raphe magnus (NRM). This effect was naloxone-reversible, and was not observed after control injections dorsal to Pgc. The percent change in spontaneous firing was significantly greater than the percent change in pinch-evoked firing. This reduction in NRM neuronal discharge may contribute to the antinociceptive effects produced by microinjection of morphine into Pgc.

AB - Microinjection of 1 μg of morphine into nucleus reticularis paragigantocellularis (Pgc) of anesthetized rats depressed both noxious-evoked and spontaneous activity of nociresponsive neurons in the nucleus raphe magnus (NRM). This effect was naloxone-reversible, and was not observed after control injections dorsal to Pgc. The percent change in spontaneous firing was significantly greater than the percent change in pinch-evoked firing. This reduction in NRM neuronal discharge may contribute to the antinociceptive effects produced by microinjection of morphine into Pgc.

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Microinjection of morphine into nucleus reticularis paragigantocellularis of the rat: suppression of noxious-evoked activity of nucleus raphe magnus neurons

Abstract

Keywords

ASJC Scopus subject areas

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