Microinjection of morphine into nucleus reticularis paragigantocellularis of the rat suppresses spontaneous activity of nucleus raphe magnus neurons

Mary Heinricher, J. Peter Rosenfeld

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Microinjection of morphine into nucleus reticularis paragigantocellularis of anesthetized rats had differential effects on spontaneous firing of neurons in nucleus raphe magnus (NRM) depending upon the dose of morphine administered. Microinjection of 1 μg of morphine, a dose which has reliable antinociceptive effects in awake animals, had predominantly suppressive effects on NRM spontaneous firing. Microinjection of 0.35 μg of morphine, a dose which has small and unreliable antinociceptive effects in awake animals, had little effect on the activity of NRM cells.

Original languageEnglish (US)
Pages (from-to)382-386
Number of pages5
JournalBrain Research
Volume272
Issue number2
DOIs
StatePublished - Aug 8 1983
Externally publishedYes

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Microinjections
Morphine
Neurons
Nucleus Raphe Magnus

Keywords

  • analgesia
  • microinjection
  • morphine
  • nucleus raphe magnus
  • nucleus reticularis paragigantocellularis
  • pain

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Microinjection of morphine into nucleus reticularis paragigantocellularis of the rat suppresses spontaneous activity of nucleus raphe magnus neurons. / Heinricher, Mary; Peter Rosenfeld, J.

In: Brain Research, Vol. 272, No. 2, 08.08.1983, p. 382-386.

Research output: Contribution to journalArticle

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