Microfluidics supporting an optical instrument for multimodal single cell biomechanics

Nathalie Nève, James K. Lingwood, Shelley R. Winn, Derek C. Tretheway, Sean Kohles

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Interfacing a novel micron-resolution particle image velocimetry and dual optical tweezers system (μPIVOT) with microfluidics facilitates the exposure of an individual biologic cell to a wide range of static and dynamic mechanical stress conditions. Single cells can be manipulated in a sequence of mechanical stresses (hydrostatic pressure variations, tension or compression, as well as shear and extensional fluid induced stresses) while measuring cellular deformation. The unique multimodal load states enable a new realm of single cell biomechanical studies.

Original languageEnglish (US)
Title of host publicationMicro and Nano Systems
PublisherAmerican Society of Mechanical Engineers (ASME)
Pages839-841
Number of pages3
Volume11
ISBN (Print)079184305X
DOIs
Publication statusPublished - 2007
EventASME 2007 International Mechanical Engineering Congress and Exposition, IMECE 2007 - Seattle, United States
Duration: Nov 11 2007Nov 15 2007

Other

OtherASME 2007 International Mechanical Engineering Congress and Exposition, IMECE 2007
CountryUnited States
CitySeattle
Period11/11/0711/15/07

    Fingerprint

ASJC Scopus subject areas

  • Mechanical Engineering

Cite this

Nève, N., Lingwood, J. K., Winn, S. R., Tretheway, D. C., & Kohles, S. (2007). Microfluidics supporting an optical instrument for multimodal single cell biomechanics. In Micro and Nano Systems (Vol. 11, pp. 839-841). American Society of Mechanical Engineers (ASME). https://doi.org/10.1115/IMECE200742004