Microfluidics supporting an optical instrument for multimodal single cell biomechanics

Nathalie Nève; James K. Lingwood; Shelley R. Winn; Derek C. Tretheway; Sean S. Kohles

doi:10.1115/IMECE2007-42004

Microfluidics supporting an optical instrument for multimodal single cell biomechanics

Nathalie Nève, James K. Lingwood, Shelley R. Winn, Derek C. Tretheway, Sean S. Kohles

Restorative Dentistry

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Interfacing a novel micron-resolution particle image velocimetry and dual optical tweezers system (μPIVOT) with microfluidics facilitates the exposure of an individual biologic cell to a wide range of static and dynamic mechanical stress conditions. Single cells can be manipulated in a sequence of mechanical stresses (hydrostatic pressure variations, tension or compression, as well as shear and extensional fluid induced stresses) while measuring cellular deformation. The unique multimodal load states enable a new realm of single cell biomechanical studies.

Original language	English (US)
Title of host publication	Proceedings of the ASME International Mechanical Engineering Congress and Exposition, IMECE 2007
Pages	839-841
Number of pages	3
DOIs	https://doi.org/10.1115/IMECE2007-42004
State	Published - May 30 2008
Event	ASME International Mechanical Engineering Congress and Exposition, IMECE 2007 - Seattle, WA, United States Duration: Nov 11 2007 → Nov 15 2007

Publication series

Name	ASME International Mechanical Engineering Congress and Exposition, Proceedings
Volume	11 PART B

Other

Other	ASME International Mechanical Engineering Congress and Exposition, IMECE 2007
Country	United States
City	Seattle, WA
Period	11/11/07 → 11/15/07

ASJC Scopus subject areas

Engineering(all)

Access to Document

10.1115/IMECE2007-42004

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Nève, N., Lingwood, J. K., Winn, S. R., Tretheway, D. C., & Kohles, S. S. (2008). Microfluidics supporting an optical instrument for multimodal single cell biomechanics. In Proceedings of the ASME International Mechanical Engineering Congress and Exposition, IMECE 2007 (pp. 839-841). (ASME International Mechanical Engineering Congress and Exposition, Proceedings; Vol. 11 PART B). https://doi.org/10.1115/IMECE2007-42004

Microfluidics supporting an optical instrument for multimodal single cell biomechanics. / Nève, Nathalie; Lingwood, James K.; Winn, Shelley R.; Tretheway, Derek C.; Kohles, Sean S.

Proceedings of the ASME International Mechanical Engineering Congress and Exposition, IMECE 2007. 2008. p. 839-841 (ASME International Mechanical Engineering Congress and Exposition, Proceedings; Vol. 11 PART B).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Nève, N, Lingwood, JK, Winn, SR, Tretheway, DC & Kohles, SS 2008, Microfluidics supporting an optical instrument for multimodal single cell biomechanics. in Proceedings of the ASME International Mechanical Engineering Congress and Exposition, IMECE 2007. ASME International Mechanical Engineering Congress and Exposition, Proceedings, vol. 11 PART B, pp. 839-841, ASME International Mechanical Engineering Congress and Exposition, IMECE 2007, Seattle, WA, United States, 11/11/07. https://doi.org/10.1115/IMECE2007-42004

Nève N, Lingwood JK, Winn SR, Tretheway DC, Kohles SS. Microfluidics supporting an optical instrument for multimodal single cell biomechanics. In Proceedings of the ASME International Mechanical Engineering Congress and Exposition, IMECE 2007. 2008. p. 839-841. (ASME International Mechanical Engineering Congress and Exposition, Proceedings). https://doi.org/10.1115/IMECE2007-42004

Nève, Nathalie ; Lingwood, James K. ; Winn, Shelley R. ; Tretheway, Derek C. ; Kohles, Sean S. / Microfluidics supporting an optical instrument for multimodal single cell biomechanics. Proceedings of the ASME International Mechanical Engineering Congress and Exposition, IMECE 2007. 2008. pp. 839-841 (ASME International Mechanical Engineering Congress and Exposition, Proceedings).

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