Microfluidics supporting an optical instrument for multimodal single cell biomechanics

Nathalie Nève, James K. Lingwood, Shelley R. Winn, Derek C. Tretheway, Sean Kohles

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Interfacing a novel micron-resolution particle image velocimetry and dual optical tweezers system (μPIVOT) with microfluidics facilitates the exposure of an individual biologic cell to a wide range of static and dynamic mechanical stress conditions. Single cells can be manipulated in a sequence of mechanical stresses (hydrostatic pressure variations, tension or compression, as well as shear and extensional fluid induced stresses) while measuring cellular deformation. The unique multimodal load states enable a new realm of single cell biomechanical studies.

Original languageEnglish (US)
Title of host publicationASME International Mechanical Engineering Congress and Exposition, Proceedings
Pages839-841
Number of pages3
Volume11 PART B
DOIs
StatePublished - 2008
EventASME International Mechanical Engineering Congress and Exposition, IMECE 2007 - Seattle, WA, United States
Duration: Nov 11 2007Nov 15 2007

Other

OtherASME International Mechanical Engineering Congress and Exposition, IMECE 2007
CountryUnited States
CitySeattle, WA
Period11/11/0711/15/07

Fingerprint

Optical instruments
Biomechanics
Microfluidics
Optical tweezers
Hydrostatic pressure
Velocity measurement
Compaction
Fluids

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Nève, N., Lingwood, J. K., Winn, S. R., Tretheway, D. C., & Kohles, S. (2008). Microfluidics supporting an optical instrument for multimodal single cell biomechanics. In ASME International Mechanical Engineering Congress and Exposition, Proceedings (Vol. 11 PART B, pp. 839-841) https://doi.org/10.1115/IMECE2007-42004

Microfluidics supporting an optical instrument for multimodal single cell biomechanics. / Nève, Nathalie; Lingwood, James K.; Winn, Shelley R.; Tretheway, Derek C.; Kohles, Sean.

ASME International Mechanical Engineering Congress and Exposition, Proceedings. Vol. 11 PART B 2008. p. 839-841.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nève, N, Lingwood, JK, Winn, SR, Tretheway, DC & Kohles, S 2008, Microfluidics supporting an optical instrument for multimodal single cell biomechanics. in ASME International Mechanical Engineering Congress and Exposition, Proceedings. vol. 11 PART B, pp. 839-841, ASME International Mechanical Engineering Congress and Exposition, IMECE 2007, Seattle, WA, United States, 11/11/07. https://doi.org/10.1115/IMECE2007-42004
Nève N, Lingwood JK, Winn SR, Tretheway DC, Kohles S. Microfluidics supporting an optical instrument for multimodal single cell biomechanics. In ASME International Mechanical Engineering Congress and Exposition, Proceedings. Vol. 11 PART B. 2008. p. 839-841 https://doi.org/10.1115/IMECE2007-42004
Nève, Nathalie ; Lingwood, James K. ; Winn, Shelley R. ; Tretheway, Derek C. ; Kohles, Sean. / Microfluidics supporting an optical instrument for multimodal single cell biomechanics. ASME International Mechanical Engineering Congress and Exposition, Proceedings. Vol. 11 PART B 2008. pp. 839-841
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