Microfluidics supporting an optical instrument for multimodal single cell biomechanics

Nathalie Nève, James K. Lingwood, Shelley R. Winn, Derek C. Tretheway, Sean S. Kohles

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Interfacing a novel micron-resolution particle image velocimetry and dual optical tweezers system (μPIVOT) with microfluidics facilitates the exposure of an individual biologic cell to a wide range of static and dynamic mechanical stress conditions. Single cells can be manipulated in a sequence of mechanical stresses (hydrostatic pressure variations, tension or compression, as well as shear and extensional fluid induced stresses) while measuring cellular deformation. The unique multimodal load states enable a new realm of single cell biomechanical studies.

Original languageEnglish (US)
Title of host publicationProceedings of the ASME International Mechanical Engineering Congress and Exposition, IMECE 2007
Pages839-841
Number of pages3
DOIs
StatePublished - May 30 2008
EventASME International Mechanical Engineering Congress and Exposition, IMECE 2007 - Seattle, WA, United States
Duration: Nov 11 2007Nov 15 2007

Publication series

NameASME International Mechanical Engineering Congress and Exposition, Proceedings
Volume11 PART B

Other

OtherASME International Mechanical Engineering Congress and Exposition, IMECE 2007
CountryUnited States
CitySeattle, WA
Period11/11/0711/15/07

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Nève, N., Lingwood, J. K., Winn, S. R., Tretheway, D. C., & Kohles, S. S. (2008). Microfluidics supporting an optical instrument for multimodal single cell biomechanics. In Proceedings of the ASME International Mechanical Engineering Congress and Exposition, IMECE 2007 (pp. 839-841). (ASME International Mechanical Engineering Congress and Exposition, Proceedings; Vol. 11 PART B). https://doi.org/10.1115/IMECE2007-42004