Microbubbles in medical imaging: Current applications and future directions

Jonathan R. Lindner

Research output: Contribution to journalArticlepeer-review

692 Scopus citations


Not all bubbles in the bloodstream are detrimental. During the past decade, contrast-enhanced ultrasound has evolved from a purely investigational tool to a routine diagnostic technique. This transformation has been facilitated by advances in the microbubble contrast agents and contrast-specific ultrasound imaging techniques. The ability to non-invasively image molecular events with targeted microbubbles is likely to be important for characterizing pathophysiology and for developing new therapeutic strategies in the treatment of cardiovascular and neoplastic diseases.

Original languageEnglish (US)
Pages (from-to)527-532
Number of pages6
JournalNature Reviews Drug Discovery
Issue number6
StatePublished - Jun 2004
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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