Microbubbles and ultrasound: a bird's eye view.

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Gas-filled microbubbles were initially used as ultrasound contrast agent because of their intravascular rheology, which is similar to that of red blood cells. Their transit through tissue can thus be quantified with ultrasound. More recently, these bubbles have been successfully used for molecular imaging by incorporating ligands on their surfaces that will adhere to cellular and other components within the microvasculature and can be detected by ultrasound. These bubbles have also been used for delivery of genes and drugs which can be released locally by disruption of the bubbles with high-energy ultrasound. Finally, bioeffects produced by localized ultrasound disruption of microbubbles have been shown to induce angiogenesis. This brief review will provide a bird's eye view of these applications.

Original languageEnglish (US)
Pages (from-to)137-148; discussion 148
JournalTransactions of the American Clinical and Climatological Association
StatePublished - 2004
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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