Abstract
High-intensity ultrasound (US) ablation produces deeper myocardial lesions than radiofrequency ablation. The presence of intravascular microbubble (MB) contrast agents enhances pulsed-wave US ablation via cavitation-related histotripsy, potentially facilitating ablation in persistently perfused/conducting myocardium. US ablation catheters were developed and tested in the presence of MBs using ex vivo and in vivo models. High-frame-rate videomicroscopy and US imaging of gel phantom models confirmed MB destruction by inertial cavitation. MB-facilitated US ablation in an ex vivo perfused myocardium model generated shallow (2 mm) lesions and, in an in vivo murine hindlimb model, reduced perfusion by 42% with perivascular hemorrhage and inflammation, but no myonecrosis.
Original language | English (US) |
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Pages (from-to) | 131-138 |
Number of pages | 8 |
Journal | Ultrasound in Medicine and Biology |
Volume | 47 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2021 |
Keywords
- Arrhythmias
- Electrophysiology
- Histotripsy
- Microbubbles
- Pulsed ultrasound ablation
ASJC Scopus subject areas
- Radiological and Ultrasound Technology
- Biophysics
- Acoustics and Ultrasonics