Micro-tattoo guided OCT imaging of site specific inflammation

Kevin G. Phillips, Niloy Choudhury, Ravikant V. Samatham, Harvinder Singh, Steven L. Jacques

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Epithelial biologists studying human skin diseases such as cancer formation and psoriasis commonly utilize mouse models to characterize the interplay among cells and intracellular signal transduction pathways that result in programmed changes in gene expression and cellular behaviors. The information obtained from animal models is useful only when phenotypic presentations of disease recapitulate those observed in humans. Excision of tissues followed by histochemical analysis is currently the primary means of establishing the morphological presentation. Non invasive imaging of animal models provides an alternate means to characterize tissue morphology associated with the disease of interest in vivo. While useful, the ability to perform in vivo imaging at different time points in the same tissue location has been a challenge. This information is key to understanding site specific changes as the imaged tissue can now be extracted and analyzed for mRNA expression. We present a method employing a micro-tattoo to guide optical coherence tomography (OCT) imaging of ultraviolet induced inflammation over time in the same tissue locations.

Original languageEnglish (US)
Title of host publicationBiomedical Applications of Light Scattering IV
DOIs
StatePublished - May 7 2010
EventBiomedical Applications of Light Scattering IV - San Francisco, CA, United States
Duration: Jan 23 2010Jan 25 2010

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7573
ISSN (Print)1605-7422

Other

OtherBiomedical Applications of Light Scattering IV
CountryUnited States
CitySan Francisco, CA
Period1/23/101/25/10

Keywords

  • Cancer formation
  • Carbon nanoparticles
  • Inflammation
  • Microneedle array
  • Optical coherence tomography

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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