Micro-tattoo guided OCT imaging of site specific inflammation

Kevin G. Phillips, Niloy Choudhury, Ravikant V. Samatham, Harvinder Singh, Steven Jacques

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Epithelial biologists studying human skin diseases such as cancer formation and psoriasis commonly utilize mouse models to characterize the interplay among cells and intracellular signal transduction pathways that result in programmed changes in gene expression and cellular behaviors. The information obtained from animal models is useful only when phenotypic presentations of disease recapitulate those observed in humans. Excision of tissues followed by histochemical analysis is currently the primary means of establishing the morphological presentation. Non invasive imaging of animal models provides an alternate means to characterize tissue morphology associated with the disease of interest in vivo. While useful, the ability to perform in vivo imaging at different time points in the same tissue location has been a challenge. This information is key to understanding site specific changes as the imaged tissue can now be extracted and analyzed for mRNA expression. We present a method employing a micro-tattoo to guide optical coherence tomography (OCT) imaging of ultraviolet induced inflammation over time in the same tissue locations.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7573
DOIs
StatePublished - 2010
EventBiomedical Applications of Light Scattering IV - San Francisco, CA, United States
Duration: Jan 23 2010Jan 25 2010

Other

OtherBiomedical Applications of Light Scattering IV
CountryUnited States
CitySan Francisco, CA
Period1/23/101/25/10

Fingerprint

Optical tomography
Optical Coherence Tomography
tomography
Tissue
Inflammation
Imaging techniques
animal models
histochemical analysis
Animals
Animal Models
Signal transduction
gene expression
Psoriasis
Skin Diseases
Gene expression
mice
Signal Transduction
Skin
cancer
Gene Expression

Keywords

  • Cancer formation
  • Carbon nanoparticles
  • Inflammation
  • Microneedle array
  • Optical coherence tomography

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Phillips, K. G., Choudhury, N., Samatham, R. V., Singh, H., & Jacques, S. (2010). Micro-tattoo guided OCT imaging of site specific inflammation. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7573). [75730S] https://doi.org/10.1117/12.842570

Micro-tattoo guided OCT imaging of site specific inflammation. / Phillips, Kevin G.; Choudhury, Niloy; Samatham, Ravikant V.; Singh, Harvinder; Jacques, Steven.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7573 2010. 75730S.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Phillips, KG, Choudhury, N, Samatham, RV, Singh, H & Jacques, S 2010, Micro-tattoo guided OCT imaging of site specific inflammation. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 7573, 75730S, Biomedical Applications of Light Scattering IV, San Francisco, CA, United States, 1/23/10. https://doi.org/10.1117/12.842570
Phillips KG, Choudhury N, Samatham RV, Singh H, Jacques S. Micro-tattoo guided OCT imaging of site specific inflammation. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7573. 2010. 75730S https://doi.org/10.1117/12.842570
Phillips, Kevin G. ; Choudhury, Niloy ; Samatham, Ravikant V. ; Singh, Harvinder ; Jacques, Steven. / Micro-tattoo guided OCT imaging of site specific inflammation. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7573 2010.
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