Mice with human livers

Markus Grompe, Stephen Strom

Research output: Contribution to journalReview article

62 Scopus citations

Abstract

Animal models are used to study many aspects of human disease and to test therapeutic interventions. However, some very important features of human biology cannot be replicated in animals, even in nonhuman primates or transgenic rodents engineered with human genes. Most human microbial pathogens do not infect animals and the metabolism of many xenobiotics is different between human beings and animals. The advent of transgenic immune-deficient mice has made it possible to generate chimeric animals harboring human tissues and cells, including hepatocytes. The liver plays a central role in many human-specific biological processes and mice with humanized livers can be used to model human metabolism, liver injury, gene regulation, drug toxicity, and hepatotropic infections.

Original languageEnglish (US)
Pages (from-to)1209-1214
Number of pages6
JournalGastroenterology
Volume145
Issue number6
DOIs
StatePublished - Dec 2013

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Keywords

  • Animal Model
  • Chimera
  • Hepatocyte
  • Humanization
  • Liver

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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